来自海洋软体动物角质滨螺的凯莱亭宁I和凯莱亭宁A是真核生物DNA聚合酶α的抑制剂。

Kelletinin I and kelletinin A from the marine mollusc Buccinulum corneum are inhibitors of eukaryotic DNA polymerase alpha.

作者信息

Orlando P, Carretta F, Grippo P, Cimino G, De Stefano S, Strazzullo G

机构信息

Istituto di Biochimica delle Proteine ed Enzimologia, I Facoltà di Medicina, Napoli, Italy.

出版信息

Experientia. 1991 Jan 15;47(1):64-6. doi: 10.1007/BF02041254.

DOI:10.1007/BF02041254

PMID:1999246

Abstract

The inhibitory effect of esters of p-hydroxybenzoic acid (kelletinins I and A), extracted from the marine gastropod Buccinulum corneum, have been tested on eukaryotic and prokaryotic enzymes of DNA metabolism such as DNA polymerases alpha and beta, DNA polymerase I, Exo III, pancreatic DNAse I, micrococcal DNAse and E. coli RNA polymerase. Kelletinin I and kelletinin A inhibit preferentially DNA polymerase alpha. The inhibitory effect of kelletinin I involves the hydroxyl group of p-hydroxybenzoic acid.

摘要

从海洋腹足纲动物角质滨螺中提取的对羟基苯甲酸酯（凯莱亭宁I和A），已针对DNA代谢的真核和原核酶进行了测试，这些酶包括DNA聚合酶α和β、DNA聚合酶I、外切核酸酶III、胰腺DNA酶I、微球菌DNA酶和大肠杆菌RNA聚合酶。凯莱亭宁I和凯莱亭宁A优先抑制DNA聚合酶α。凯莱亭宁I的抑制作用涉及对羟基苯甲酸的羟基。