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Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells.

作者信息

Silvestri I, Albonici L, Ciotti M, Lombardi M P, Sinibaldi P, Manzari V, Orlando P, Carretta F, Strazzullo G, Grippo P

机构信息

Dipartimento di Medicina Sperimentale e Scienze Biochimiche, II Università di Roma Tor Vergata, Italy.

出版信息

Experientia. 1995 Nov 15;51(11):1076-80. doi: 10.1007/BF01946920.

DOI:10.1007/BF01946920
PMID:7498449
Abstract

Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.

摘要

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Kelletinin I and kelletinin A from the marine mollusc Buccinulum corneum are inhibitors of eukaryotic DNA polymerase alpha.来自海洋软体动物角质滨螺的凯莱亭宁I和凯莱亭宁A是真核生物DNA聚合酶α的抑制剂。
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