普拉德-威利综合征能量消耗和身体活动评估测量系统的开发与验证
Development and validation of a measurement system for assessment of energy expenditure and physical activity in Prader-Willi syndrome.
作者信息
Chen K Y, Sun M, Butler M G, Thompson T, Carlson M G
机构信息
Department of Medicine, Vanderbilt University, Nashville, TN 37232-4453, USA.
出版信息
Obes Res. 1999 Jul;7(4):387-94. doi: 10.1002/j.1550-8528.1999.tb00422.x.
OBJECTIVE
The morbid obesity associated with Prader-Willi syndrome (PWS) may result from either excessive energy intake or reduced energy expenditure (EE). In this report, we describe the development and validation of an Activity-Energy Measurement System (AEMS) to measure EE and physical activity components in an environment approximating free-living conditions.
RESEARCH METHODS AND PROCEDURES
The AEMS consists of a live-in, whole-room indirect calorimeter equipped with a novel force platform floor system to enable simultaneous measurements of EE, physical activity, and work efficiency during spontaneous activities and standardized exercises. Free-living physical activity and estimated free-living EE are measured using portable triaxial accelerometers individually calibrated in each subject during their stay in the AEMS.
RESULTS
Representative data from two PWS patients and two matched control (CTR) subjects displayed EE during their inactive lifestyles.
DISCUSSION
This combination of methods will allow the quantification of daily EE and its components, the amount and energy cost of physical activity, and the relationships between body composition and EE, in order to determine their roles in the development and maintenance of the morbid obesity in PWS.
目的
普拉德-威利综合征（PWS）相关的病态肥胖可能源于能量摄入过多或能量消耗（EE）减少。在本报告中，我们描述了一种活动能量测量系统（AEMS）的开发与验证，该系统用于在接近自由生活条件的环境中测量EE和身体活动成分。
研究方法与步骤
AEMS由一个内置的全室间接热量计组成，配备了新型测力平台地板系统，能够在自发活动和标准化运动期间同时测量EE、身体活动和工作效率。使用便携式三轴加速度计测量自由生活中的身体活动和估计的自由生活EE，每个受试者在入住AEMS期间单独进行校准。
结果
来自两名PWS患者和两名匹配对照（CTR）受试者的代表性数据显示了他们非活动生活方式下的EE。
讨论
这种方法组合将能够量化每日EE及其组成部分、身体活动的量和能量消耗，以及身体成分与EE之间的关系，从而确定它们在PWS病态肥胖的发生和维持中的作用。
Zotero 插件