对具有皮肤和呼吸道表现的三聚氰酸三缩水甘油酯（TGIC）过敏
Sensitization to triglycidylisocyanurate (TGIC) with cutaneous and respiratory manifestations.
作者信息
Meuleman L, Goossens A, Linders C, Rochette F, Nemery B
机构信息
Department of Dermatology, University Hospital, K.U. Leuven, Belgium.
出版信息
Allergy. 1999 Jul;54(7):752-6. doi: 10.1111/j.1398-9995.1999.00103.x.
The case is presented of a man with allergic contact dermatitis and occupational asthma due to triglycidylisocyanurate (TGIC), which is used as a hardener in thermosetting powder paint. The contact dermatitis was confirmed by patch testing (TGIC 0.5% and 5% in petrolatum), and the occupational asthma was confirmed by bronchial provocation testing: two challenges to an aerosol of lactose containing TGIC (0.05% and 0.1%, w/w, each for 0.5+1+2+4 min) led to a maximal decrease in FEV1 of 22% and 31% after 6 and 4 h, respectively. Skin prick tests with unconjugated TGIC were possibly positive. This case confirms that exposure to TGIC in powder paints may cause not only contact dermatitis, but also occupational asthma.
本文报告了一例因三缩水甘油基异氰脲酸酯（TGIC）导致过敏性接触性皮炎和职业性哮喘的男性病例。TGIC用作热固性粉末涂料的固化剂。斑贴试验（凡士林基质中含0.5%和5%的TGIC）证实了接触性皮炎，支气管激发试验证实了职业性哮喘：两次吸入含TGIC的乳糖气雾剂（0.05%和0.1%，w/w，每次分别为0.5 + 1 + 2 + 4分钟），分别在6小时和4小时后导致第一秒用力呼气量（FEV1）最大下降22%和31%。未结合的TGIC皮肤点刺试验可能为阳性。该病例证实，接触粉末涂料中的TGIC不仅可能导致接触性皮炎，还可能导致职业性哮喘。
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