[一项关于自我检查用于早期发现乳腺癌的前瞻性随机研究的中期结果（俄罗斯/圣彼得堡/世界卫生组织）]

[Interim results of a prospective randomized study of self-examination for early detection of breast cancer (Russia/St.Petersburg/WHO)].

作者信息

Semiglazov V F, Moiseenko V M, Manikhas A G, Protsenko S A, Kharikova R S, Popova R T, Migmanova N Sh, Orlov A A, Barash N Iu, Ivanova O A, Ivanov V G

机构信息

Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.

出版信息

Vopr Onkol. 1999;45(3):265-71.

PMID:10443229

Abstract

Training in breast self-examination (BSE) technique involved 57,712 women, aged 40-64, at 14 out of randomly selected out-patient hospitals in St. Petersburg (1985-1989). Another 64,759 women selected at another 14 out-patient hospitals were in control. All patients with detected tumor pathology of the breast were biopsied and treated at the Institute's Clinic. The study focused on breast cancer incidence, survival and mortality. More women in the BSE group sought medical advice for suspected pathology (4,300) than those in control (2,438; p < 0.05). There were 493 cases of breast cancer in the BSE group with 157 fatalities, 446 cases of breast cancer with 167 fatalities in the control group. There was no significant difference in tumor stage. Nine-year survival (after Kaplan-Meyer) from the time of tumor detection was 65% in the study group and 55% in control (log rank 0.774; p > 0.05). There has been no significant difference in death rates in both groups for the past ten years. The study is to continue until the year 2001.

摘要

1985年至1989年期间，在圣彼得堡随机挑选的14家门诊医院，对57712名年龄在40至64岁之间的女性进行了乳房自我检查（BSE）技术培训。另外从其他14家门诊医院挑选的64759名女性作为对照。所有检测出乳房肿瘤病变的患者均在该研究所的诊所进行了活检和治疗。该研究聚焦于乳腺癌的发病率、生存率和死亡率。接受BSE培训的组中，因疑似病变寻求医疗建议的女性（4300人）多于对照组（2438人；p<0.05）。BSE组有493例乳腺癌病例，其中157例死亡；对照组有446例乳腺癌病例，167例死亡。肿瘤分期无显著差异。从肿瘤检测时起，研究组的9年生存率（根据Kaplan-Meyer法）为65%，对照组为55%（对数秩检验为0.774；p>0.05）。在过去十年中，两组的死亡率无显著差异。该研究将持续到2001年。