Semiglazov V F, Moiseenko V M, Protsenko S A, Bavli I L, Orlov A A, Ivanova O A, Barash N I, Chagunava O L, Golubeva O M, Migmanova N S, Seleznev I K, Popova R T, Diatchenko O T, Kozhevnikov S I, Aleksandrova G I, Sanchakova A V, Kharikova R S, Liubomirova N K, Ivanova G V, Azeev V F, Chuprakova I S
Vopr Onkol. 1996;42(4):49-55.
Although an absolute difference of 10% (65,4 vs. 54,9%) in 5- and 9-year survival in breast cancer patients was recorded between the self-examination and control groups a large-scale randomized population-controlled study of 122,471 females has failed to provide significant differences (Log-rank - 0,774, p > 0.05). No significant decrease in mortality was observed in the self-examination group as compared with the untrained controls. As a result of providing more information to the population on risk factors. twice as many of the trained females consulted oncologists. Also, the number of early detection of breast tumor (T1-2NOMO) in both groups was 1,5-2,5 times that recorded elsewhere. Since 3,55 per 1,000 patients with breast tumors per year, aged 50-59, died of cardio-vascular disease, i.e. 3,1 times the expected 1,16 per 1,000, more attention should be focused on timely diagnosis and treatment of concomitant cardio-vascular pathology.
尽管自我检查组和对照组的乳腺癌患者在5年和9年生存率上有10%的绝对差异(65.4%对54.9%),但一项针对122471名女性的大规模随机人群对照研究未能发现显著差异(对数秩检验-0.774,p>0.05)。与未经培训的对照组相比,自我检查组的死亡率没有显著降低。由于向人群提供了更多关于风险因素的信息,接受培训的女性咨询肿瘤学家的人数增加了一倍。此外,两组中乳腺肿瘤早期检测(T1-2N0M0)的数量是其他地方记录数量的1.5至2.5倍。由于每年每1000名50至59岁的乳腺肿瘤患者中有3.55人死于心血管疾病,即预期每1000人中有1.16人的3.1倍,因此应更加关注伴随心血管疾病的及时诊断和治疗。