Brunner D, Buhot M C, Hen R, Hofer M
Department of Psychology, Hunter College of the City University of New York and New York State Psychiatric Institute, 10032, USA.
Behav Neurosci. 1999 Jun;113(3):587-601. doi: 10.1037//0735-7044.113.3.587.
This study describes the development of anxiety and motor activation in mice lacking the serotonin (5HT) 1B receptor and in wild type controls and characterizes their early mother-infant interactions. In the isolation-induced ultrasonic vocalization paradigm, 5HT1B knockout pups vocalized less and were hyperactive, rearing, jumping, and rolling more often than wild type pups. One week postpartum, 5HT1B knockout mothers spent 20% more of their time outside the nest and were also hyperactive, rearing and climbing to the edge of the cage more often than the wild type mothers. There were no genotype effects on pup retrieval. Knockout adults were less anxious in the elevated plus-maze, defecated less, and head-dipped more, although none of the standard measures of anxiety (time and entries in the open arms) were different. 5HT1B knockout mice of both sexes were hyperactive during both the light and the dark phases of the 24-hr cycle. Thus, 5HT1B knockout mice show reduced anxiety and are hyperactive throughout their life.
本研究描述了缺乏5-羟色胺（5HT）1B受体的小鼠和野生型对照小鼠中焦虑和运动激活的发展情况，并对它们早期的母婴互动进行了特征描述。在隔离诱导的超声波发声范式中，5HT1B基因敲除幼崽发声较少且多动，比起野生型幼崽更频繁地直立、跳跃和翻滚。产后一周，5HT1B基因敲除的母鼠在巢外的时间多20%，且也多动，比起野生型母鼠更频繁地直立并爬到笼子边缘。在幼崽找回方面没有基因型效应。基因敲除的成年小鼠在高架十字迷宫中焦虑程度较低，排便较少，头部下垂更多，尽管焦虑的标准测量指标（在开放臂中的时间和进入次数）没有差异。在24小时周期的光照和黑暗阶段，两性的5HT1B基因敲除小鼠都多动。因此，5HT1B基因敲除小鼠表现出焦虑减少且一生都多动。
