Wang Z, Yu G, Cascio C, Liu Y, Gingrich B, Insel T R
Department of Psychiatry and Behavioral Sciences and Graduate Program in Neuroscience, Emory University, USA.
Behav Neurosci. 1999 Jun;113(3):602-11. doi: 10.1037//0735-7044.113.3.602.
This study examined the role of dopamine (DA) in partner preference (PP) formation in female prairie voles (Microtus ochrogaster). The nonspecific DA antagonist haloperidol blocked mating-induced PP, whereas the nonspecific DA agonist apomorphine induced PP without mating. The D2 antagonist eticlopride, but not the D1 antagonist SCH23390, blocked PP, whereas the D2 agonist quinpirole, but not the D1 agonist SKF38393, induced PP without mating. Injections of eticlopride before or immediately after mating, but not 24 hr after mating, impaired PP, indicating that DA's effects were not due to an interference with mating or sensory recognition. Finally, intracerebroventricular injections of eticlopride diminished PP. Together, these data suggest that mating-induced PP requires activation of D2 receptors and that social experience may activate dopaminergic pathways, with enduring effects on behavior.
本研究考察了多巴胺（DA）在雌性草原田鼠（Microtus ochrogaster）配偶偏好（PP）形成中的作用。非特异性DA拮抗剂氟哌啶醇可阻断交配诱导的PP，而非特异性DA激动剂阿扑吗啡在未交配情况下可诱导PP。D2拮抗剂依托必利可阻断PP，而D1拮抗剂SCH23390则不能，D2激动剂喹吡罗可在未交配情况下诱导PP，而D1激动剂SKF38393则不能。在交配前或交配后立即注射依托必利，但在交配后24小时注射则不会损害PP，这表明DA的作用并非由于干扰交配或感觉识别。最后，脑室内注射依托必利可减弱PP。总之，这些数据表明交配诱导的PP需要激活D2受体，且社交经验可能激活多巴胺能通路，对行为产生持久影响。
