D2 拮抗剂在发育过程中可降低成年雌性草原田鼠（Microtus ochrogaster）的焦虑和杀婴行为。
D2 antagonist during development decreases anxiety and infanticidal behavior in adult female prairie voles (Microtus ochrogaster).
机构信息
Department of Psychology, University of California at Davis, One Shields Ave., Davis, CA 95616, USA.
出版信息
Behav Brain Res. 2010 Jun 26;210(1):127-30. doi: 10.1016/j.bbr.2010.02.010. Epub 2010 Feb 10.
Abstract
On postnatal day 8, prairie vole pups were randomly assigned a treatment of 1mg/kg SKF38393 (D1 agonist), quinpirole (D2 agonist), SCH23390 (D1 antagonist), eticlopride (D2 antagonist), or saline vehicle. As adults, females treated with eticlopride exhibited reduced anxiety-like behavior in an elevated plus maze and a reduction in infanticidal behavior. These behavioral effects were not seen in males. These data demonstrate that a single exposure to a D2 antagonist during development can have persistent, sex-specific effects on behavior into adulthood.
摘要
产后第 8 天，草原田鼠幼崽被随机分配接受以下处理：1mg/kg SKF38393（D1 激动剂）、喹吡罗（D2 激动剂）、SCH23390（D1 拮抗剂）、依托利定（D2 拮抗剂）或生理盐水。作为成年动物，接受依托利定处理的雌性表现出在高架十字迷宫中的焦虑样行为减少和杀婴行为减少。这些行为效应在雄性中并未观察到。这些数据表明，在发育过程中单次暴露于 D2 拮抗剂会对成年后的行为产生持久的、性别特异性影响。
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