Melanson K J, Westerterp-Plantenga M S, Saris W H, Smith F J, Campfield L A
Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands.
Am J Physiol. 1999 Aug;277(2):R337-45. doi: 10.1152/ajpregu.1999.277.2.R337.
We assessed the extent to which a possible synchronization between transient blood glucose declines and spontaneous meal initiation would lend support to the interpretation of a preload study with isoenergetic (1 MJ) isovolumetric high-fat or simple carbohydrate (CHO) preload drinks. Ten men (18-30 yr) fasted overnight and then were time blinded and made aware that they could request meals anytime. At first meal requests, volunteers consumed a preload; ad libitum meals were offered at subsequent requests. Postabsorptively, transient declines in blood glucose were associated with meal requests (chi(2) = 8.29). Subsequent meal requests occurred during "dynamic declines" in blood glucose after the peak induced by drink consumption (100%). These meal requests took twice as long to occur after high-fat than after CHO preloads (fat = 126 +/- 21, CHO = 65 +/- 15 min), consistent with differences in interpolated 65-min satiety scores (fat = 38 +/- 8.2, CHO = 16 +/- 4). Postprandially, transient blood glucose declines were associated with meal requests (chi(2) = 4.30). Spontaneous meal initiations were synchronized with transient and dynamic blood glucose declines. Synchronization of intermeal interval and dynamic declines related to higher satiating efficiency from high-fat preloads than from simple CHO preloads.
我们评估了短暂性血糖下降与自发进餐开始之间的可能同步程度，这将为等能量（1兆焦耳）等容性高脂肪或简单碳水化合物（CHO）预负荷饮料的预负荷研究解释提供支持。10名男性（18 - 30岁）禁食过夜，然后对时间进行盲法处理，并告知他们可以随时要求进餐。在首次提出进餐请求时，志愿者饮用一种预负荷饮料；后续请求时提供随意进食的餐食。在吸收后状态下，血糖的短暂下降与进餐请求相关（卡方 = 8.29）。后续进餐请求发生在饮用饮料诱导的峰值后血糖的“动态下降”期间（100%）。高脂肪预负荷后出现这些进餐请求的时间是碳水化合物预负荷后的两倍（脂肪组 = 126 ± 21分钟，碳水化合物组 = 65 ± 15分钟），这与内插的65分钟饱腹感评分差异一致（脂肪组 = 38 ± 8.2，碳水化合物组 = 16 ± 4）。餐后，血糖的短暂下降与进餐请求相关（卡方 = 4.30）。自发进餐开始与短暂性和动态性血糖下降同步。进餐间隔与动态下降的同步与高脂肪预负荷比简单碳水化合物预负荷具有更高的饱腹感效率有关。
