Section of Psychoneurobiology, Center of Brain, Behavior and Metabolism (CBBM), University of Luebeck, Ratzeburger Allee 160, 23562, Luebeck, Germany.
Eur J Nutr. 2021 Oct;60(7):3887-3895. doi: 10.1007/s00394-021-02563-7. Epub 2021 Apr 23.
Satiety is a crucial factor in the attempt to reduce food intake for long-term body weight loss. Since there is evidence for a negative correlation between cerebral energy levels and food intake, the provision of the primary energy substrate glucose to the brain through oral ingestion of carbohydrates could trigger feelings of satiety. Therefore, we hypothesized that a low-calorie saccharide preload would increase satiety, reduce subsequent food intake, and thereby decrease overall calorie consumption.
In a randomized single-blind crossover study, 17 healthy young normal-weight men received saccharide (26 kcal in total) or placebo capsules 30 min before a standardized breakfast buffet. We analysed food intake from the test buffet as well as plasma glucose and serum insulin levels.
The saccharide preload reduced food intake from the buffet by 168 (± 34) kcal (p < 0.001) compared to control. This corresponds to a net reduction in total calorie consumption by 142 (± 34) kcal (p < 0.001) or 9.3% due to saccharide capsules.
A very low-calorie saccharide preload considerably reduces subsequent food intake leading to decreased overall calorie consumption. A saccharide preload before meals could, therefore, be a promising support for reducing caloric intake.
DRKS00010281 (date of registration: 11.04.2016).
饱腹感是减少食物摄入以实现长期体重减轻的关键因素。由于大脑能量水平与食物摄入之间存在负相关的证据，因此通过口服摄入碳水化合物为大脑提供主要能量底物葡萄糖可能会引发饱腹感。因此，我们假设低卡路里的糖负荷会增加饱腹感，减少随后的食物摄入，从而减少总卡路里的消耗。
在一项随机、单盲、交叉研究中，17 名健康的年轻正常体重男性在标准化早餐自助餐前 30 分钟接受糖（总共 26 卡路里）或安慰剂胶囊。我们分析了测试自助餐中的食物摄入量以及血浆葡萄糖和血清胰岛素水平。
与对照组相比，糖负荷使自助餐中的食物摄入量减少了 168（±34）卡路里（p<0.001）。这相当于总卡路里消耗减少了 142（±34）卡路里（p<0.001）或由于糖胶囊减少了 9.3%。
极低卡路里的糖负荷可显著减少随后的食物摄入，从而降低总卡路里消耗。因此，餐前糖负荷可能是减少热量摄入的一种有前途的辅助手段。
DRKS00010281（注册日期：2016 年 4 月 11 日）。
