Golka K, Bandel T, Reckwitz T, Urfer W, Bolt H M, Bremicker K D, Neugebauer W, Schulze H
Institut für Arbeitsphysiologie, Universität Dortmund.
Urologe A. 1999 Jul;38(4):358-63. doi: 10.1007/s001200050298.
Aim of this case-control study, performed on 412 male bladder cancer cases and 414 controls with benign prostatic hyperplasia in a former area of coal, iron and steel industries in Germany, was to identify occupations with an increased bladder cancer risk. In bladder cancer cases, smokers were overrepresented (58.3%) compared to controls (35.2%). The percentage of patients who had stopped smoking for at least 10 years did not differ in cases (10.2%) and controls (9.7%). Significantly elevated smoking-adjusted bladder cancer odds ratios (MH) were observed in painters and lacquers (MH 2.24, 95% CI 1.07-5.13), chemistry-related occupations (MH 2.44, 95% CI 1.05-5.67), coke plant workers (MH 2.89, 95% CI 1.16-7.16) and hard coal miners (MH 2.33, 95% CI 1.52-3.58). Significantly decreased smoking-adjusted bladder cancer odds ratios (MH) were observed in businessmen (MH 0.64, 95% CI 0.45-0.92) and office personnel (MH 0.58, 95% CI 0.41-0.81). In these two groups a relevant exposure to occupational bladder carcinogens is not likely.
本病例对照研究在德国一个曾经的煤炭、钢铁工业区对412例男性膀胱癌患者和414例良性前列腺增生对照者进行，目的是确定膀胱癌风险增加的职业。在膀胱癌患者中，吸烟者的比例（58.3%）高于对照组（35.2%）。戒烟至少10年的患者比例在病例组（10.2%）和对照组（9.7%）中没有差异。在油漆工和喷漆工（MH 2.24，95%可信区间1.07 - 5.13）、化学相关职业者（MH 2.44，95%可信区间1.05 - 5.67）、炼焦厂工人（MH 2.89，95%可信区间1.16 - 7.16）和硬煤矿工（MH 2.33，95%可信区间1.52 - 3.58）中观察到吸烟调整后的膀胱癌优势比显著升高。在商人（MH 0.64，95%可信区间0.45 - 0.92）和办公室职员（MH 0.58，95%可信区间0.41 - 0.81）中观察到吸烟调整后的膀胱癌优势比显著降低。在这两组中，不太可能接触到职业性膀胱致癌物。
