rox1和rox2 RNA是补偿体的重要组成部分，补偿体在果蝇中介导剂量补偿。

The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila.

作者信息

Franke A, Baker B S

机构信息

Department of Biological Sciences, Stanford University, California 94305, USA.

出版信息

Mol Cell. 1999 Jul;4(1):117-22. doi: 10.1016/s1097-2765(00)80193-8.

DOI:10.1016/s1097-2765(00)80193-8

PMID:10445033

Abstract

The rox1 and rox2 RNAs have been suggested to be components of the dosage compensation machinery in Drosophila. We show that both rox RNAs colocalize with the male-specific lethal proteins at hundreds of specific bands along the male X chromosome. The rox RNAs and MSL proteins also colocalize with the X chromosome in all somatic cells and are expressed in the same temporal pattern throughout development. Genetic analysis shows that the functions of the rox genes are redundant and required for the association of the MSL proteins with the male X chromosome. These data provide compelling evidence for a direct function of the rox RNAs in dosage compensation.

摘要

rox1和rox2 RNA被认为是果蝇剂量补偿机制的组成部分。我们发现，这两种rox RNA与雄性特异性致死蛋白在雄性X染色体上的数百个特定条带处共定位。rox RNA和MSL蛋白在所有体细胞中也与X染色体共定位，并且在整个发育过程中以相同的时间模式表达。遗传分析表明，rox基因的功能是冗余的，并且是MSL蛋白与雄性X染色体结合所必需的。这些数据为rox RNA在剂量补偿中的直接作用提供了有力证据。