Krekmanova L, Carlstedt-Duke J, Marcus C, Dahllöf G
Department of Pediatric Dentistry, School of Dentistry, Karolinska Institutet, Stockholm, Sweden.
Acta Odontol Scand. 1999 Apr;57(2):93-6. doi: 10.1080/000163599428977.
The aim of this investigation was to present the 2-year follow-up results of a longitudinal study examining the influence of growth hormone (GH) substitution on dental maturity in healthy children of short stature (height <2 SD). At baseline, the children were divided into a GH-deficient group and a GH non-deficient group, and comparisons were made with healthy controls (height between -2 SD and 2 SD) and between the short stature groups. The GH-substituted group included 24 children (8 F, 16 M) with a mean chronological age of 12.20 +/- 2.40 years, whereas the GH non-substituted group included 19 children (5 F, 14 M) with a mean chronological age of 11.00 +/- 2.40 years. The corresponding age- and sex-matched control groups constituted 48 and 36 children, respectively. The mean dental age in the GH-substituted group was 11.60 +/- 2.70 years, compared to their healthy controls 12.40 +/- 2.60 years (P< 0.05). The dental age for the GH non-substituted children was 10.20 +/- 2.60 years compared to their controls 11.90 +/- 2.60 years (P< 0.001). GH-substituted children show an acceleration in their dental maturity in contrast to controls, whereas in non-substituted children the acceleration is less pronounced.
本研究的目的是呈现一项纵向研究的2年随访结果，该研究考察了生长激素（GH）替代疗法对健康矮小儿童（身高<2标准差）牙齿成熟度的影响。在基线时，将儿童分为生长激素缺乏组和非生长激素缺乏组，并与健康对照组（身高在-2标准差至2标准差之间）以及矮小儿童组进行比较。生长激素替代组包括24名儿童（8名女性，16名男性），平均实际年龄为12.20±2.40岁，而非生长激素替代组包括19名儿童（5名女性，14名男性），平均实际年龄为11.00±2.40岁。相应的年龄和性别匹配的对照组分别有48名和36名儿童。生长激素替代组的平均牙齿年龄为11.60±2.70岁，而其健康对照组为12.40±2.60岁（P<0.05）。非生长激素替代儿童的牙齿年龄为10.20±2.60岁，而其对照组为11.90±2.60岁（P<0.001）。与对照组相比，生长激素替代儿童的牙齿成熟加速，而非替代儿童的加速则不太明显。
