Krekmanova L, Carlstedt-Duke J, Brönnegård M, Marcus C, Gröndahl E, Modéer T, Dahllöf G
Department of Pediatric Dentistry, School of Dentistry, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.
Eur J Oral Sci. 1997 Dec;105(6):551-6. doi: 10.1111/j.1600-0722.1997.tb00216.x.
The aim of this investigation was to study dental maturity in healthy prepubertal children of short stature (height<-2 SD), with or without growth hormone (GH) deficiency, compared to healthy controls. The GH-deficient group (GH level<10.0 microg/l) included 29 children (11 female, 18 male) with a mean age of 10.2+/-2.2 years. The GH non-deficient group consisted of 17 children (5 female, 12 male) with a mean age of 8.5+/-2.1 years. All the children were evaluated for serum concentrations of IGF-1, alkaline phosphatase (ALP), triiodthyronin (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and fasting plasma insulin; height and bone age were also recorded. Dental maturity was determined from panoramic radiographs. The mean difference between the dental and chronological ages was -0.67+/-0.89 years in the GH-deficient group compared to 0.23+/-1.07 years in their controls: in the GH non-deficient group the difference was -0.95+/-0.82 years compared to controls 0.16+/-1.06 years in their controls. Compared to chronological age, both bone and dental age were lower in the GH-deficient and GH non-deficient groups. It is concluded that children of short stature, both GH-deficient and GH non-deficient. exhibit a delayed dental age compared to their chronological age- and sex-matched controls. A multiple stepwise regression analysis showed that the sitting height and GH level were the only significant factors associated with dental maturity.
本研究的目的是研究身材矮小（身高低于-2标准差）的健康青春期前儿童（无论有无生长激素（GH）缺乏）与健康对照组相比的牙齿成熟情况。生长激素缺乏组（生长激素水平<10.0微克/升）包括29名儿童（11名女性，18名男性），平均年龄为10.2±2.2岁。生长激素非缺乏组由17名儿童（5名女性，12名男性）组成，平均年龄为8.5±2.1岁。所有儿童均接受了胰岛素样生长因子-1、碱性磷酸酶（ALP）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）和空腹血浆胰岛素的血清浓度评估；还记录了身高和骨龄。牙齿成熟度由全景X线片确定。生长激素缺乏组牙齿年龄与实际年龄的平均差异为-0.67±0.89岁，而对照组为0.23±1.07岁：生长激素非缺乏组的差异为-0.95±0.82岁，而对照组为0.16±1.06岁。与实际年龄相比，生长激素缺乏组和生长激素非缺乏组的骨龄和牙齿年龄均较低。得出的结论是，身材矮小的儿童，无论生长激素缺乏与否，与年龄和性别匹配的对照组相比，牙齿年龄均延迟。多元逐步回归分析表明，坐高和生长激素水平是与牙齿成熟度相关的唯一显著因素。
