Jones K L, Kong M F, Berry M K, Rayner C K, Adamson U, Horowitz M
Department of Medicine, University of Adelaide, Royal Adelaide Hospital, South Australia.
Am J Gastroenterol. 1999 Aug;94(8):2074-9. doi: 10.1111/j.1572-0241.1999.01280.x.
The aim of this study was to determine whether variations in the blood glucose concentration within the normal postprandial range affect the gastrokinetic action of erythromycin.
Six healthy male volunteers, aged 20-33 yr underwent measurements of gastric emptying on 2 separate days; blood glucose concentrations were maintained at approximately 4 mmol/L (72 mg/dl) on 1 day and at 8 mmol/L (144 mg/dl) on the other. The order of the two studies was randomized and they were separated by 4-7 days. On both days, erythromycin (3 mg/kg) was administered intravenously over 15 min immediately before consumption of 300 g minced beef labeled with 20 MBq 99mTc-sulphur colloid chicken liver and 150 ml water labeled with 67Ga-EDTA.
Gastric emptying of solid (p < 0.05) and liquid (p < 0.0001) were slower at a blood glucose concentration of 8 mmol/L (144 mg/dl) when compared to 4 mmol/L (72 mg/dl). The slowing of gastric emptying was associated with greater retention of both solid and liquid in the proximal (p < 0.06) and distal (p < 0.01) stomach.
After administration of erythromycin, gastric emptying and intragastric distribution of solids and liquids is influenced by physiological changes in the blood glucose concentration.
本研究旨在确定正常餐后范围内血糖浓度的变化是否会影响红霉素的胃肠动力作用。
6名年龄在20 - 33岁的健康男性志愿者在2个不同日期接受胃排空测量；一天血糖浓度维持在约4 mmol/L（72 mg/dl），另一天维持在8 mmol/L（144 mg/dl）。两项研究的顺序随机安排，间隔4 - 7天。在这两天，在食用标有20 MBq 99mTc - 硫胶体鸡肝的300 g碎牛肉和标有67Ga - EDTA的150 ml水之前15分钟，静脉注射红霉素（3 mg/kg）。
与血糖浓度4 mmol/L（72 mg/dl）相比，血糖浓度为8 mmol/L（144 mg/dl）时固体（p < 0.05）和液体（p < 0.0001）的胃排空更慢。胃排空减慢与固体和液体在胃近端（p < 0.06）和远端（p < 0.01）的潴留增加有关。
给予红霉素后，固体和液体的胃排空及胃内分布受血糖浓度生理变化的影响。
