• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

猴子实验性内毒素休克模型及其治疗控制

A model of experimental endotoxin shock in monkeys and its therapeutic control.

作者信息

Hájek M, Trcka V, Vanĕcek M, Helfert I, Misák J

出版信息

Z Exp Chir. 1978;11(5):317-21.

PMID:104460
Abstract

The course and therapy of endotoxin shock were studied in 34 monkeys Macaca mulatta. E. coli endotoxin was infused intravenously to conscious animals. The individual responses to a dose of 3 mg . kg-1 exhibited a considerable variability. A part of shocked animals were successfully rescued by a combined infusion of dopamine, hydrocortisone, and dextran; untreated animals died of endotoxin shock. Morphological changes in their parenchymatous organs were little marked in the acute experiment.

摘要

在34只恒河猴身上研究了内毒素休克的病程及治疗方法。将大肠杆菌内毒素静脉注入清醒的动物体内。对3mg·kg-1剂量的个体反应表现出相当大的变异性。一部分休克动物通过联合输注多巴胺、氢化可的松和右旋糖酐成功获救;未经治疗的动物死于内毒素休克。在急性实验中,其实质器官的形态学变化并不明显。

相似文献

1
A model of experimental endotoxin shock in monkeys and its therapeutic control.猴子实验性内毒素休克模型及其治疗控制
Z Exp Chir. 1978;11(5):317-21.
2
Combined therapy of experimental endotoxin shock in monkeys.猴子实验性内毒素休克的联合治疗
Acta Univ Carol Med (Praha). 1980;26(3-4):141-60.
3
The effects of hydrocortisone and dopamine on circulatory alterations in experimental acute endotoxin shock in dogs.氢化可的松和多巴胺对犬实验性急性内毒素休克循环系统改变的影响。
Z Exp Chir. 1978;11(5):322-7.
4
Acute endotoxin shock in the dog and an attempt at its therapy.犬急性内毒素休克及其治疗尝试。
Acta Univ Carol Med Monogr. 1979;94:1-114.
5
Pathophysiology of endotoxin shock in primates and the effect of various therapeutic agents.灵长类动物内毒素休克的病理生理学及各种治疗药物的作用。
Obstet Gynecol. 1969 Aug;34(2):271-6.
6
The effect of low molecular weight dextran on haemodynamics and respiratory function during endotoxin-induced shock.低分子量右旋糖酐对内毒素性休克期间血流动力学和呼吸功能的影响。
Arch Emerg Med. 1992 Mar;9(1):1-8. doi: 10.1136/emj.9.1.1.
7
Comparison of hemodynamic and regional blood flow changes at equivalent stages of endotoxin and hemorrhagic shock.内毒素休克和失血性休克同等阶段血流动力学及局部血流变化的比较。
J Trauma. 1976 Nov;16(11):886-97. doi: 10.1097/00005373-197611000-00007.
8
ENDOTOXIN SHOCK IN THE PRIMATE: TREATMENT WITH PHENOXYBENZAMINE.灵长类动物的内毒素休克:用酚苄明治疗
J Clin Invest. 1964 Feb;43(2):279-84. doi: 10.1172/JCI104912.
9
Effect of dopamine infusion on the hemodynamics of normal and sympathectomized rhesus monkeys in endotoxin shock.多巴胺输注对内毒素休克状态下正常及交感神经切除的恒河猴血流动力学的影响。
Circ Shock. 1977;4(3):271-8.
10
A primate model for prolonged endotoxin shock. Blood-vascular reactions and effects of glucocorticoid treatment.
Lab Invest. 1978 Apr;38(4):511-23.

引用本文的文献

1
Changes of inflammation-associated cytokine expressions during early phase of experimental endotoxic shock in macaques.猕猴实验性内毒素休克早期炎症相关细胞因子表达的变化
World J Gastroenterol. 2004 Oct 15;10(20):3026-33. doi: 10.3748/wjg.v10.i20.3026.