猴子实验性内毒素休克模型及其治疗控制
A model of experimental endotoxin shock in monkeys and its therapeutic control.
作者信息
Hájek M, Trcka V, Vanĕcek M, Helfert I, Misák J
出版信息
Z Exp Chir. 1978;11(5):317-21.
PMID:104460
Abstract
The course and therapy of endotoxin shock were studied in 34 monkeys Macaca mulatta. E. coli endotoxin was infused intravenously to conscious animals. The individual responses to a dose of 3 mg . kg-1 exhibited a considerable variability. A part of shocked animals were successfully rescued by a combined infusion of dopamine, hydrocortisone, and dextran; untreated animals died of endotoxin shock. Morphological changes in their parenchymatous organs were little marked in the acute experiment.
摘要
在34只恒河猴身上研究了内毒素休克的病程及治疗方法。将大肠杆菌内毒素静脉注入清醒的动物体内。对3mg·kg-1剂量的个体反应表现出相当大的变异性。一部分休克动物通过联合输注多巴胺、氢化可的松和右旋糖酐成功获救；未经治疗的动物死于内毒素休克。在急性实验中，其实质器官的形态学变化并不明显。
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A model of experimental endotoxin shock in monkeys and its therapeutic control.猴子实验性内毒素休克模型及其治疗控制
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