Buku A
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA.
Peptides. 1999;20(3):415-20. doi: 10.1016/s0196-9781(98)00167-3.
The solid phase synthesis of mast degranulating peptide (MCD peptide) raised the possibility of preparing analogs and examining the pharmacology and the proposed role of this peptide as a potential agent in allergy and inflammation. MCD peptide, a cationic 22-amino acid residue peptide with two disulfide bridges, causes mast cell degranulation and histamine release at low concentrations and has anti-inflammatory activity at higher concentrations. Because of these unique immunologic properties, MCD peptide may serve as a useful tool for studying secretory mechanisms of inflammatory cells such as mast cells, basophils, and leukocytes, leading to the design of compounds with therapeutic potential.
肥大细胞脱粒肽（MCD肽）的固相合成增加了制备类似物以及研究该肽作为过敏和炎症潜在药物的药理学及假定作用的可能性。MCD肽是一种具有两个二硫键的阳离子22氨基酸残基肽，在低浓度时可引起肥大细胞脱粒和组胺释放，在高浓度时具有抗炎活性。由于这些独特的免疫学特性，MCD肽可能成为研究肥大细胞、嗜碱性粒细胞和白细胞等炎症细胞分泌机制的有用工具，从而有助于设计具有治疗潜力的化合物。
