Akbar A, Rees J H, Nyamugunduru G, English M W, Spencer D A, Weller P H
Paediatric Respiratory and Cystic Fibrosis Unit, The Birmingham Children's Hospital NHS Trust, UK.
Acta Paediatr. 1999 Jul;88(7):783-5. doi: 10.1080/08035259950169116.
Hypomagnesaemia in children with cystic fibrosis (CF) is under-recognized. We report a child with CF who developed significant hypomagnesaemia following intravenous (i.v.) treatment with aminoglycosides for exacerbations of Pseudomonas aeruginosa infection. Three additional cases have also been observed. Investigations in two patients have revealed excessive renal loss of magnesium. It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia, and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides.
囊性纤维化（CF）患儿的低镁血症未得到充分认识。我们报告了一名CF患儿，在因铜绿假单胞菌感染加重而接受氨基糖苷类药物静脉注射治疗后出现了严重的低镁血症。另外还观察到3例病例。对两名患者的调查显示肾脏过度丢失镁。据推测，反复使用氨基糖苷类药物的累积效应导致肾小管损伤，进而引起低镁血症，我们建议对所有接受多疗程氨基糖苷类药物治疗的CF患者定期监测血清镁，以筛查这一问题。
