Rohrer D, Salmon D P, Wixted J T, Paulsen J S
Department of Psychology, University of South Florida, Tampa 33620-8200, USA.
Neuropsychology. 1999 Jul;13(3):381-8. doi: 10.1037//0894-4105.13.3.381.
Alzheimer's disease (AD) and Huntington's disease (HD) impair performance on semantic memory tasks, but researchers disagree on whether AD and HD cause these impairments in the same manner. According to one view, AD disrupts the storage of semantic memories, whereas HD disrupts the retrieval of semantic memories. Dissenters argue that AD, like HD, disrupts retrieval. In this study, participants generated category exemplars (e.g., kinds of fruits) for 1 min, and response latencies were examined. Relative to healthy controls, the 12 AD patients produced a larger proportion of responses earlier in the recall period, consistent with the view that AD patients quickly exhaust their limited supply of items in storage. By contrast, the 12 HD patients produced a larger proportion of their responses late in the recall period, consistent with the view that HD slows retrieval.
阿尔茨海默病（AD）和亨廷顿舞蹈病（HD）会损害语义记忆任务的表现，但研究人员对于AD和HD是否以相同方式导致这些损害存在分歧。根据一种观点，AD会破坏语义记忆的存储，而HD会破坏语义记忆的提取。持不同意见者则认为，AD与HD一样，会破坏提取过程。在本研究中，参与者在1分钟内生成类别范例（如水果种类），并检查反应潜伏期。与健康对照组相比，12名AD患者在回忆期早期产生的反应比例更大，这与AD患者迅速耗尽其有限存储项目供应的观点一致。相比之下，12名HD患者在回忆期后期产生的反应比例更大，这与HD会减慢提取速度的观点一致。
