Randolph C
Rutgers University.
J Clin Exp Neuropsychol. 1991 Jul;13(4):479-94. doi: 10.1080/01688639108401065.
A priming task involving a word-stem completion paradigm was administered to patients with Alzheimer's disease (AD), patients with Huntington's disease (HD), and normal control subjects. The task was done under conditions of both implicit and explicit recall. Explicit and implicit recall were positively correlated in all three groups. After controlling for explicit recall ability through ANCOVA, AD patients were found to be normally susceptible to the effects of priming on implicit recall. HD patients, however, exhibited significantly increased susceptibility to priming, suggesting that they may have carried out the implicit task in a manner different from that of normals and AD patients. In a second experiment, AD patients were found to supply words of significantly lower association strength than the other two groups in a "free association" task using words from a published list of word association norms. This apparent degradation of semantic memory was found to be strongly correlated with explicit recall performance, suggesting that explicit, implicit, and semantic memory functions decline in parallel in AD. Results are discussed with respect to the difficulties inherent in attempts to demonstrate selective impairments of conceptually distinct forms of memory.
对阿尔茨海默病（AD）患者、亨廷顿舞蹈病（HD）患者和正常对照受试者进行了一项涉及词干补全范式的启动任务。该任务在隐式和显式回忆条件下完成。在所有三组中，显式和隐式回忆呈正相关。通过协方差分析控制显式回忆能力后，发现AD患者对启动对隐式回忆的影响正常敏感。然而，HD患者对启动的敏感性显著增加，这表明他们执行隐式任务的方式可能与正常人和AD患者不同。在第二个实验中，在一项使用已发表的词联想规范列表中的单词进行的“自由联想”任务中，发现AD患者提供的单词联想强度明显低于其他两组。这种语义记忆的明显衰退与显式回忆表现密切相关，表明在AD中，显式、隐式和语义记忆功能并行下降。针对试图证明概念上不同形式的记忆存在选择性损伤所固有的困难，对结果进行了讨论。
