发现1,6-萘啶类化合物作为一类新型强效且选择性的人巨细胞病毒抑制剂。 - Suppr

Suppr

超能文献

Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors.

作者信息

Chan L, Jin H, Stefanac T, Lavallée J F, Falardeau G, Wang W, Bédard J, May S, Yuen L

机构信息

BioChem Pharma Inc., 275 Armand-Frappier Boulevard, Laval, Québec, Canada H7V 4A7.

出版信息

J Med Chem. 1999 Aug 12;42(16):3023-5. doi: 10.1021/jm9902483.

DOI:10.1021/jm9902483

PMID:10447945

Abstract

摘要

相似文献

Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors.发现1,6-萘啶类化合物作为一类新型强效且选择性的人巨细胞病毒抑制剂。

J Med Chem. 1999 Aug 12;42(16):3023-5. doi: 10.1021/jm9902483.

Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.一种强效大环1,6-萘啶抗人巨细胞病毒（HCMV）抑制剂的设计与合成

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1693-5. doi: 10.1016/j.bmcl.2005.01.050.

Substituted 1,6-naphthyridines as human cytomegalovirus inhibitors: conformational requirements.作为人巨细胞病毒抑制剂的取代1,6-萘啶：构象要求

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2769-70. doi: 10.1016/s0960-894x(00)00568-0.

Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines.基于分子内氢键作用的1,6-萘啶设计与合成新型高效人巨细胞病毒（HCMV）抑制剂

Bioorg Med Chem Lett. 2001 Jan 22;11(2):103-5. doi: 10.1016/s0960-894x(00)00607-7.

Discovery of a novel series of inhibitors of human cytomegalovirus primase.人类巨细胞病毒引发酶新型抑制剂系列的发现

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4879-83. doi: 10.1016/j.bmcl.2006.06.066. Epub 2006 Jun 30.

Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism.基于亲脂性烷基呋喃嘧啶双脱氧核苷发现人巨细胞病毒（HCMV）抑制剂新家族：通过新型非核苷机制发挥作用。

J Med Chem. 2004 Mar 25;47(7):1847-51. doi: 10.1021/jm030857h.

Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.7-苄基-4-羟基-1,5-萘啶-2(1H)-酮HIV整合酶抑制剂的合成与抗病毒活性

J Med Chem. 2009 May 14;52(9):2754-61. doi: 10.1021/jm801404b.

SAR studies on a novel series of human cytomegalovirus primase inhibitors.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2188-92. doi: 10.1016/j.bmcl.2007.01.109. Epub 2007 Feb 8.

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.4-苄氧基-γ-磺内酯衍生物：一类新型人巨细胞病毒和水痘带状疱疹病毒非核苷抑制剂的发现

J Med Chem. 2009 Mar 26;52(6):1582-91. doi: 10.1021/jm8014662.

Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV.疱疹病毒的硫脲抑制剂。第2部分：巨细胞病毒的N-苄基-N'-芳基硫脲抑制剂。

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3401-6. doi: 10.1016/j.bmcl.2004.04.093.

引用本文的文献

New synthetic chitosan Schiff bases bearing pyranoquinolinone or benzonaphthyridine and their silver nanoparticles derivatives with potential activity as antioxidant and molecular docking study for EGFR inhibitors.新型含吡喃喹啉酮或苯并萘啶的合成壳聚糖席夫碱及其具有抗氧化活性潜力的银纳米颗粒衍生物与表皮生长因子受体（EGFR）抑制剂的分子对接研究

RSC Adv. 2024 Sep 20;14(41):29919-29933. doi: 10.1039/d4ra05117c. eCollection 2024 Sep 18.

HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein-Protein Interaction and Targeting by Triazole-Based Compounds through In Silico Approaches.单纯疱疹病毒 1 糖蛋白 D 及其表面受体：通过基于三唑的化合物通过计算方法评估蛋白质-蛋白质相互作用和靶向性。

Int J Mol Sci. 2023 Apr 11;24(8):7092. doi: 10.3390/ijms24087092.

Thermal Rearrangement of 5-(2-Hydroxy-6-oxocyclohexyl)-5-chromeno[2,3-]pyridines.5-(2-羟基-6-氧代环己基)-5-色烯并[2,3-b]吡啶的热重排。

Molecules. 2023 Mar 31;28(7):3139. doi: 10.3390/molecules28073139.

Synthesis of Novel Benzo[][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors.新型苯并[][1,6]萘啶衍生物的合成及其作为 MAO 抑制剂骨架的潜力研究。

Molecules. 2023 Feb 9;28(4):1662. doi: 10.3390/molecules28041662.

Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines.功能化 1,6-萘啶的合成及抗癌性能研究。

Top Curr Chem (Cham). 2021 Feb 24;379(2):13. doi: 10.1007/s41061-020-00314-6.

Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.酰胺键生物等排体：策略、合成与成功。

J Med Chem. 2020 Nov 12;63(21):12290-12358. doi: 10.1021/acs.jmedchem.0c00530. Epub 2020 Aug 4.

An expedient synthesis, acetylcholinesterase inhibitory activity, and molecular modeling study of highly functionalized hexahydro-1,6-naphthyridines.高官能化六氢-1,6-萘啶的简便合成、乙酰胆碱酯酶抑制活性及分子模拟研究

Biomed Res Int. 2015;2015:965987. doi: 10.1155/2015/965987. Epub 2015 Jan 29.

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.1-[ω-(苯氧基)烷基]尿嘧啶衍生物及其类似物的合成及抗 HCMV 活性。

Bioorg Med Chem. 2013 Jul 15;21(14):4151-7. doi: 10.1016/j.bmc.2013.05.009. Epub 2013 May 16.

Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines.新型3H-苯并[b]吡唑并[3,4-h]-1,6-萘啶和3H-吡啶并[2,3-b]吡唑并[3,4-h]-1,6-萘啶的合成及抗单纯疱疹病毒-1活性评价

Org Med Chem Lett. 2012 Feb 1;2(1):3. doi: 10.1186/2191-2858-2-3.

Effect of specific solute-solvent interaction and electron donor-acceptor substituents of novel pyrazolo naphthyridines on fluorescence.新型吡唑并萘啶类化合物中特定溶质-溶剂相互作用和供电子-受电子取代基对荧光的影响。

J Fluoresc. 2011 Jan;21(1):461-71. doi: 10.1007/s10895-010-0707-0. Epub 2010 Sep 30.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验