卷曲蛋白-10（Frizzled-10）的分子克隆，卷曲蛋白基因家族的一个新成员。
Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family.
作者信息
Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M
机构信息
Genetics Division, National Cancer Center Research Institute, Tsukiji 5-chome, Chuo-ku, Tokyo, 104-0045, Japan.
出版信息
Biochem Biophys Res Commun. 1999 Aug 19;262(1):39-43. doi: 10.1006/bbrc.1999.1161.
The Frizzled genes encode WNT receptors. Frizzled-10 (FZD10), a novel member of the Frizzled gene family, has been cloned and characterized. Nucleotide sequence analysis showed that human FZD10 gene encodes a seven-transmembrane-receptor of 581 amino acids, with the N-terminal cysteine-rich domain and the C-terminal Ser/Thr-Xxx-Val motif. Larger amounts of FZD10 mRNA, 4.0 kb in size, were detected in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, FZD10 mRNA was abundant in the cerebellum. Among cancer cell lines, FZD10 was highly expressed in a cervical cancer cell line, HeLa S3, and moderately in a colon cancer cell line, SW480. The FZD10 gene was mapped to human chromosome 12q24.33. FZD10 shares 65.7% amino-acid identity with Frizzled-9 (FZD9). FZD10 and FZD9 constitute a subfamily among the Frizzled genes.
卷曲蛋白基因编码WNT受体。卷曲蛋白-10（FZD10）是卷曲蛋白基因家族的一个新成员，已被克隆和鉴定。核苷酸序列分析表明，人类FZD10基因编码一个由581个氨基酸组成的七跨膜受体，具有N端富含半胱氨酸的结构域和C端的Ser/Thr-Xxx-Val基序。在胎盘和胎儿肾脏中检测到大量大小为4.0 kb的FZD10 mRNA，其次是胎儿肺和脑。在成人大脑中，FZD10 mRNA在小脑中含量丰富。在癌细胞系中，FZD10在宫颈癌细胞系HeLa S3中高表达，在结肠癌细胞系SW480中中度表达。FZD10基因定位于人类染色体12q24.33。FZD10与卷曲蛋白-9（FZD9）的氨基酸同一性为65.7%。FZD10和FZD9在卷曲蛋白基因中构成一个亚家族。
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