Ray P K
Department of Immunotechnology and Environmental Sciences, Bose Institute, Calcutta, India.
Mol Cell Biochem. 1999 Jun;196(1-2):117-23.
Stress genes can be ascribed to have been generated by the organism for their intrinsic urge to survive against the changing environmental odds, during the evolutionary process. This concept has been supported by a large number of reports describing individual types of phenomena. These have been reconciled and globalised in terms of their relevance in this article. Supporting evidences have been drawn from the literature which indicated that by using different types of inducer one can express heat shock proteins. Similarly, several types of stress inducers, such as calorie restriction, LPS stimulation and Staphylococcal Protein-A stimulation, it was possible to induce a wide array of biological, biochemical and immunological reactions. Such biological reactions rendered protection against toxic, carcinogenic, metabolic, as well as biological stresses induced by microorganisms. Heat shock proteins have been implicated as having a role in providing resistance to the host against different types of stressors. In this article, some mechanistic schemes have been proposed as possible pathways globalising such phenomena. A minute amount of stress inducers has been observed to have helped expression of stress resistance genes, providing increased capability to the host to protect itself against myriads of both biotic and abiotic stressors. More understanding about such phenomena would help in keeping our physiological systems vigilant and our bodies healthy, fighting out the stress-related events effectively.
应激基因可以被认为是生物体在进化过程中为了自身抵御不断变化的环境不利因素的生存本能而产生的。这一概念得到了大量描述各种现象的报告的支持。本文根据它们的相关性对这些报告进行了梳理和综合。支持证据来自文献,这些文献表明通过使用不同类型的诱导剂可以表达热休克蛋白。同样,几种类型的应激诱导剂,如热量限制、脂多糖刺激和葡萄球菌蛋白A刺激,都有可能诱导广泛的生物学、生物化学和免疫反应。这种生物学反应能够抵御由微生物引起的毒性、致癌、代谢以及生物应激。热休克蛋白被认为在赋予宿主抵抗不同类型应激源的能力方面发挥作用。在本文中,提出了一些机制方案作为使这些现象综合化的可能途径。已观察到微量的应激诱导剂有助于应激抗性基因的表达,从而增强宿主保护自身免受无数生物和非生物应激源影响的能力。对这类现象有更多的了解将有助于使我们的生理系统保持警觉,使我们的身体保持健康,有效地应对与应激相关的事件。