有丝分裂原和应激反应途径：哺乳动物和酵母中的丝裂原活化蛋白激酶级联反应和磷酸酶调节
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast.
作者信息
Waskiewicz A J, Cooper J A
机构信息
Fred Hutchinson Cancer Research Center, Seattle, USA.
出版信息
Curr Opin Cell Biol. 1995 Dec;7(6):798-805. doi: 10.1016/0955-0674(95)80063-8.
PMID:8608010
Abstract
Evolutionarily conserved from yeast to man, mitogen-activated protein kinase (MAPK) pathways respond to a variety of disparate signals which induce differentiation, proliferation, or changes in intracellular enzyme regulation. Recent advances have identified two new mammalian MAPK relatives, JNK1 and p38, and the pathways which are responsible for their activation.
摘要
从酵母到人类，丝裂原活化蛋白激酶（MAPK）通路在进化上是保守的，它能对各种不同的信号作出反应，这些信号可诱导分化、增殖或引起细胞内酶调节的变化。最近的研究进展已鉴定出两种新的哺乳动物MAPK家族成员，即JNK1和p38，以及负责激活它们的通路。
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