Holt P G, Stumbles P A, McWilliam A S
TVW Telethon Institute for Child Health Research, Perth, Australia.
J Leukoc Biol. 1999 Aug;66(2):272-5. doi: 10.1002/jlb.66.2.272.
Recent reports indicate that mucosal tissues contain dendritic cell (DC) populations that exhibit phenotypic features distinct from those at more studied sites such as skin. In particular, mucosal DC populations display very rapid baseline turnover rates, which increase in response to local inflammatory stimuli. This property is likely to be central to the role of mucosal DC in surveillance of these front-line tissues for incoming microbial pathogens. As we discuss, it may also indirectly account for the "Th2 default," which is the recognized hallmark of mucosal immune system in the steady state.
最近的报告表明，黏膜组织中含有树突状细胞（DC）群体，这些群体表现出与皮肤等研究较多部位的DC不同的表型特征。特别是，黏膜DC群体的基线更新率非常快，在局部炎症刺激下会增加。这种特性可能是黏膜DC在监测这些一线组织以检测入侵微生物病原体方面发挥作用的核心。正如我们所讨论的，它也可能间接解释了“Th2默认状态”，这是稳态下黏膜免疫系统公认的标志。
