Stumbles Philip A, Upham John W, Holt Patrick G
Telethon Institute for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth, Western Australia.
APMIS. 2003 Jul-Aug;111(7-8):741-55. doi: 10.1034/j.1600-0463.2003.11107806.x.
The large quantities and complex mixtures of antigens encountered daily at airway mucosal and alveolar surfaces pose a major challenge to maintenance of immunological homeostasis in the respiratory tract. Amongst this myriad of antigens, the immune system must discriminate between innocuous components that can be tolerated by the host and potentially life-threatening pathogens that require a rapid immune response. Dendritic cells (DC) represent the principal cell type at these sites capable of processing antigens and delivering signals that initiate tolerogenic or immunogenic immune responses. This review will discuss the role of DC at the "front-line" of immune surveillance and homeostasis within the respiratory tract and their role in the pathogenesis of respiratory disease.
气道黏膜和肺泡表面每天都会遇到大量且复杂的抗原混合物，这对维持呼吸道免疫稳态构成了重大挑战。在这无数的抗原中，免疫系统必须区分宿主能够耐受的无害成分和需要快速免疫反应的潜在致命病原体。树突状细胞（DC）是这些部位的主要细胞类型，能够处理抗原并传递引发耐受性或免疫原性免疫反应的信号。本综述将讨论DC在呼吸道免疫监视和稳态的“前线”中的作用及其在呼吸道疾病发病机制中的作用。
