Humeniuk Piotr, Dubiela Pawel, Hoffmann-Sommergruber Karin
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna 1090, Austria.
Int J Mol Sci. 2017 Jul 11;18(7):1491. doi: 10.3390/ijms18071491.
Dendritic cells (DCs) are the most important antigen presenting cells to activate naïve T cells, which results in the case of Type 1 allergies in a Type 2 helper T cell (Th2)-driven specific immune response towards allergens. So far, a number of different subsets of specialized DCs in different organs have been identified. In the recent past methods to study the interaction of DCs with allergenic proteins, their different uptake and processing mechanisms followed by the presentation to T cells were developed. The following review aims to summarize the most important characteristics of DC subsets in the context of allergic diseases, and highlights the recent findings. These detailed studies can contribute to a better understanding of the pathomechanisms of allergic diseases and contribute to the identification of key factors to be addressed for therapeutic interventions.
树突状细胞（DCs）是激活初始T细胞的最重要抗原呈递细胞，在1型过敏反应中，这会导致由2型辅助性T细胞（Th2）驱动的针对过敏原的特异性免疫反应。到目前为止，已经在不同器官中鉴定出许多不同的特异性DC亚群。最近，开发了研究DCs与变应原性蛋白相互作用、其不同摄取和加工机制以及随后呈递给T细胞的方法。以下综述旨在总结变应性疾病背景下DC亚群的最重要特征，并突出最新研究结果。这些详细研究有助于更好地理解变应性疾病的发病机制，并有助于确定治疗干预中需要解决的关键因素。
