Hoq M M, Suzutani T, Nakaya K, Yoshida I, Ogasawara M, Takeda Y, Shibaki T, Itohara S, Yamamoto H, Azuma M
Department of Microbiology, Asahikawa Medical College, Japan.
Microbiol Immunol. 1999;43(5):491-3. doi: 10.1111/j.1348-0421.1999.tb02433.x.
Normal mice inoculated intravenously with 50 microg trehalose-6,6'-dimycolate, a glycolipid component of the cell wall of Mycobacterium, in an oil-in-water emulsion (TDM emulsion) acquired a high resistance to intranasal lethal infection of an influenza virus. In contrast, TDM emulsion-treated T-cell receptor delta gene mutant (TCR delta-/-) mice acquired insufficient resistance against the lethal influenza virus infection. The patterns of insufficient resistance were identical to the results obtained previously with mice which were depleted of T-lymphocytes bearing gammadelta T-cell receptors (gammadelta T-cells) by in vivo administration of anti-gammadelta T-cell receptor monoclonal antibody (Hoq et al, J. Gen. Virol. 78: 1597-1603, 1997). These results strongly suggest that the gammadelta T-cells play an important non-specific role in resistance against influenza virus infection.
将50微克海藻糖-6,6'-二霉菌酸酯（一种分枝杆菌细胞壁的糖脂成分）以水包油乳剂（TDM乳剂）的形式静脉注射给正常小鼠，这些小鼠对流感病毒的鼻内致死性感染获得了高度抗性。相比之下，经TDM乳剂处理的T细胞受体δ基因缺陷型（TCRδ-/-）小鼠对致死性流感病毒感染获得的抗性不足。抗性不足的模式与先前通过体内给予抗γδT细胞受体单克隆抗体使携带γδT细胞受体的T淋巴细胞（γδT细胞）耗竭的小鼠所得到的结果相同（Hoq等人，《普通病毒学杂志》78: 1597 - 1603, 1997）。这些结果有力地表明，γδT细胞在抵抗流感病毒感染中发挥着重要的非特异性作用。
