Scarborough G A
Department of Pharmacology, CB 7365 Mary Ellen Jones Building, University of North Carolina, Chapel Hill, NC 27599, USA.
Curr Opin Cell Biol. 1999 Aug;11(4):517-22. doi: 10.1016/S0955-0674(99)80075-1.
The P-type ATPases are integral membrane proteins that generate essential transmembrane ion gradients in virtually all living cells. The structures of two of these have recently been elucidated at a resolution of 8 A. When considered together with the large body of biochemical information that has accrued for these transporters and for enzymes in general, this new structural information is providing tantalizing insights regarding the molecular mechanism of active ion transport catalyzed by these proteins.
P型ATP酶是整合膜蛋白，几乎在所有活细胞中产生必需的跨膜离子梯度。其中两种的结构最近已在8埃的分辨率下得到阐明。当与积累起来的关于这些转运蛋白以及一般酶的大量生化信息结合起来考虑时，这些新的结构信息正为这些蛋白质催化的主动离子转运的分子机制提供诱人的见解。
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