脊椎动物中的Wnt信号传导与背腹轴的特化
Wnt signaling and dorso-ventral axis specification in vertebrates.
作者信息
Sokol S Y
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Molecular Medicine Unit, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Massachusetts 02215, USA.
出版信息
Curr Opin Genet Dev. 1999 Aug;9(4):405-10. doi: 10.1016/S0959-437X(99)80061-6.
The dorso-ventral axis is specified in vertebrates through the formation of a dorsal signaling center known as the Spemann organizer. This process depends on signal transduction by beta-catenin that can be regulated by secreted Wnt proteins. Recent discoveries of new players in this signaling pathway have narrowed down the search for the initial cues for axis specification in vertebrate embryos.
在脊椎动物中，背腹轴是通过形成一个称为施佩曼组织者的背侧信号中心来确定的。这个过程依赖于β-连环蛋白的信号转导，而β-连环蛋白可由分泌的Wnt蛋白调节。最近在这个信号通路中发现的新成员，缩小了对脊椎动物胚胎轴形成初始线索的搜索范围。
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