Jönsson S A, Luts A, Guldberg-Kjaer N, Ohman R
Department of Clinical Neuroscience, Division of Psychiatry, Lund University Hospital, S-22185 Lund, Sweden.
Eur Arch Psychiatry Clin Neurosci. 1999;249(4):169-73. doi: 10.1007/s004060050083.
Hippocampal pyramidal neuron size was determined in all Cornu Ammonis subregions - CA1-CA4 - in five chronic schizophrenic men and compared with eight controls matched with respect to age and sex. Four out of five probands and the same eight controls had been examined in a previous study showing a significantly lower cell count and disorientation of pyramidal cells in the CA1- CA3 subregions of the schizophrenics. There was also a negative correlation between the total number of cells and the number of disoriented cells. In this study it was shown that the schizophrenic probands also had significantly smaller neurons in all subregions. There was a significant negative correlation between pyramidal neuron size and the number of disarrayed neurons in each subregion, and there was a significant positive correlation between neuron size and the total number of pyramidal cells in CA1 and CA2, but not in CA3 and CA4. The consistency of hippocampal anomalies in these schizophrenics is, thus, demonstrated by the statistical relations between the different parameters examined.
测定了5名慢性精神分裂症男性患者海马角所有亚区（海马1-4区）的锥体细胞大小，并与8名年龄和性别匹配的对照者进行比较。在之前的一项研究中，对5名先证者中的4名以及同样的8名对照者进行了检查，结果显示精神分裂症患者海马1-3区的细胞计数显著降低，锥体细胞排列紊乱。细胞总数与排列紊乱的细胞数之间也存在负相关。在本研究中发现，精神分裂症先证者所有亚区的神经元也显著较小。每个亚区的锥体细胞大小与排列紊乱的神经元数量之间存在显著负相关，在海马1区和2区，神经元大小与锥体细胞总数之间存在显著正相关，但在海马3区和4区则不然。因此，通过所检测的不同参数之间的统计关系，证明了这些精神分裂症患者海马异常的一致性。
