毛透明蛋白，一种角质形成细胞和生殖细胞中的锌指蛋白，与核糖体RNA基因启动子结合。
Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter.
作者信息
Iuchi S, Green H
机构信息
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston MA 02115, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9628-32. doi: 10.1073/pnas.96.17.9628.
Abstract
Basonuclin is a protein containing three pairs of C(2)H(2) zinc fingers. The protein has been found in the basal (germinal) cell layer of stratified squamous epithelia, such as the epidermis, and in germ cells of the testis and ovary. We show here that the human protein has specific affinity for a segment of the promoter of the gene for rRNA. Basonuclin interacts with two separate parts of the promoter, each possessing dyad symmetry. The upstream part, but not the downstream part, is known to bind UBF1, a transcription factor for rDNA. Basonuclin is likely to be a cell-type-specific regulatory protein for rDNA transcription.
摘要
锌指蛋白是一种含有三对C(2)H(2)锌指结构的蛋白质。该蛋白已在复层鳞状上皮的基底（生发）细胞层中发现，如表皮，以及在睾丸和卵巢的生殖细胞中发现。我们在此表明，人类该蛋白对核糖体RNA基因启动子的一段序列具有特异性亲和力。锌指蛋白与启动子的两个不同部分相互作用，每个部分都具有二元对称性。已知上游部分而非下游部分可结合上游结合因子1（UBF1），它是一种rDNA转录因子。锌指蛋白可能是一种rDNA转录的细胞类型特异性调节蛋白。
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Exp Dermatol. 2000 Jun;9(3):178-84. doi: 10.1034/j.1600-0625.2000.009003178.x.
2
Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation.TATA结合蛋白-TAFI复合物SL1募集至人核糖体DNA启动子是由上游结合因子（UBF）的羧基末端激活结构域介导的，并受UBF磷酸化调控。
Mol Cell Biol. 1999 Apr;19(4):2872-9. doi: 10.1128/MCB.19.4.2872.
3
Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein.核糖体RNA转录因子上游结合因子的磷酸化促进其与TATA结合蛋白的结合。
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5
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An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids.在发育中的精子细胞的中心体、线粒体和顶体中，锌指蛋白的意外定位。
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