Weiner L, Green H
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Differentiation. 1998 Sep;63(5):263-72. doi: 10.1046/j.1432-0436.1998.6350263.x.
Basonuclin, a zinc-finger protein, is found in stratified squamous epithelia and hair follicles. In the basal keratinocytes of mouse epidermis, basonuclin is detected mainly in the cytoplasm. During the development of murine hair follicles, this protein concentrates in the nuclei of the basal cells that form the primary hair germs. As follicle morphogenesis proceeds, the epithelial cells possessing nuclear basonuclin invade the dermis and surround the follicular papilla. In mature anagen follicles, nuclear basonuclin is principally restricted to the basal layers of the outer root sheath and bulbar matrix; these regions are known to contain cells capable of proliferation, and to lack the features of terminal differentiation. During catagen, the compartment of cells containing nuclear basonuclin regresses, and in telogen, only a small number of these cells remain to form the secondary hair germ at the follicle base. During the next anagen, this basonuclin-containing population expands and regenerates the hair-producing portion of the follicle. It is concluded that in all hair cycles, the transient segment of the follicle originates from germinative cells possessing nuclear basonuclin.
碱性成纤维细胞生长因子结合蛋白（Basonuclin）是一种锌指蛋白，存在于复层鳞状上皮和毛囊中。在小鼠表皮的基底角质形成细胞中，碱性成纤维细胞生长因子结合蛋白主要在细胞质中被检测到。在小鼠毛囊发育过程中，这种蛋白质集中在形成初级毛芽的基底细胞的细胞核中。随着毛囊形态发生的进行，含有细胞核碱性成纤维细胞生长因子结合蛋白的上皮细胞侵入真皮并包围毛囊乳头。在成熟的生长期毛囊中，细胞核碱性成纤维细胞生长因子结合蛋白主要局限于外根鞘和球部基质的基底层；已知这些区域含有能够增殖的细胞，并且缺乏终末分化的特征。在退行期，含有细胞核碱性成纤维细胞生长因子结合蛋白的细胞区域退化，在休止期，只有少数这些细胞留在毛囊基部形成次级毛芽。在下一个生长期，这个含有碱性成纤维细胞生长因子结合蛋白的群体扩大并再生毛囊的毛发产生部分。可以得出结论，在所有毛发周期中毛囊的短暂部分都起源于具有细胞核碱性成纤维细胞生长因子结合蛋白的生发细胞。
