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锌指蛋白Basonuclin与上皮细胞的扩张和增殖相关。

Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation.

作者信息

Tseng H

机构信息

Department of Dermatology and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Front Biosci. 1998 Sep 1;3:D985-8. doi: 10.2741/a338.

DOI:10.2741/a338
PMID:9727087
Abstract

Basonuclin is a zinc finger protein first described as a keratinoycte specific protein present in various stratified squamous epithelia found in epidermis, esophagis, cornea and virgina. Recent studies showed that its distribution also includes the germ cells of testis and ovary. The presence of basonuclin appeared always related to the cellular proliferative ability not just cell division, for it was found both in dividing and quiescent cells. Basonuclin disappeared when a cell became post-mitotic. This review examines the latest findings about the distribution, molecular and cellular biology of basonuclin and discusses its possible role in cell proliferation.

摘要

碱性成纤维细胞生长因子是一种锌指蛋白，最初被描述为一种存在于表皮、食管、角膜和阴道等多种复层鳞状上皮中的角质形成细胞特异性蛋白。最近的研究表明，它的分布还包括睾丸和卵巢的生殖细胞。碱性成纤维细胞生长因子的存在似乎总是与细胞增殖能力有关，而不仅仅是细胞分裂，因为在分裂细胞和静止细胞中都发现了它。当细胞进入有丝分裂后期时，碱性成纤维细胞生长因子就会消失。这篇综述探讨了关于碱性成纤维细胞生长因子分布、分子和细胞生物学的最新发现，并讨论了它在细胞增殖中可能发挥的作用。

相似文献

1
Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation.锌指蛋白Basonuclin与上皮细胞的扩张和增殖相关。
Front Biosci. 1998 Sep 1;3:D985-8. doi: 10.2741/a338.
2
Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis.在精子发生过程中，锌指蛋白basonuclin从小鼠生殖细胞核易位至精子的中段。
Biol Reprod. 1998 Aug;59(2):388-94. doi: 10.1095/biolreprod59.2.388.
3
Basonuclin in murine corneal and lens epithelia correlates with cellular maturation and proliferative ability.鼠角膜和晶状体上皮中的角蛋白12与细胞成熟和增殖能力相关。
Differentiation. 1999 Dec;65(4):221-7. doi: 10.1046/j.1432-0436.1999.6540221.x.
4
Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin.锌指蛋白basonuclin的一个高度保守的同源物：Basonuclin 2
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3468-73. doi: 10.1073/pnas.0400268101. Epub 2004 Feb 26.
5
Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter.毛透明蛋白，一种角质形成细胞和生殖细胞中的锌指蛋白，与核糖体RNA基因启动子结合。
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9628-32. doi: 10.1073/pnas.96.17.9628.
6
Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.碱性成核蛋白与角质形成细胞增殖能力及终末分化缺失的关联。
J Cell Biol. 1994 Jul;126(2):495-506. doi: 10.1083/jcb.126.2.495.
7
Basonuclin: a keratinocyte protein with multiple paired zinc fingers.毛透明蛋白：一种具有多个成对锌指结构的角质形成细胞蛋白。
Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10311-5. doi: 10.1073/pnas.89.21.10311.
8
Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes.Basonuclin与人类角质形成细胞有丝分裂染色体上的核糖体RNA基因相关。
J Cell Sci. 1999 Sep;112 Pt 18:3039-47. doi: 10.1242/jcs.112.18.3039.
9
Alternative subcellular locations of keratinocyte basonuclin.角质形成细胞锌指蛋白的其他亚细胞定位。
Exp Dermatol. 2000 Jun;9(3):178-84. doi: 10.1034/j.1600-0625.2000.009003178.x.
10
Basonuclin as a cell marker in the formation and cycling of the murine hair follicle.作为小鼠毛囊形成和循环中细胞标志物的毛细胞核蛋白
Differentiation. 1998 Sep;63(5):263-72. doi: 10.1046/j.1432-0436.1998.6350263.x.

引用本文的文献

1
Basonuclin-1 modulates epithelial plasticity and TGF-β1-induced loss of epithelial cell integrity.Basonuclin-1 调节上皮细胞可塑性和 TGF-β1 诱导的上皮细胞完整性丧失。
Oncogene. 2015 Feb 26;34(9):1185-95. doi: 10.1038/onc.2014.54. Epub 2014 Mar 24.
2
Recurrent microdeletions of 15q25.2 are associated with increased risk of congenital diaphragmatic hernia, cognitive deficits and possibly Diamond--Blackfan anaemia.15q25.2 微缺失的反复发生与先天性膈疝、认知缺陷和可能的 Diamond-Blackfan 贫血的风险增加有关。
J Med Genet. 2010 Nov;47(11):777-81. doi: 10.1136/jmg.2009.075903. Epub 2010 Oct 4.
3
An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells.
肺癌细胞中与 rRNA 表达和 rRNA 单核苷酸多态性频率相关的基因间非编码 rRNA。
PLoS One. 2009 Oct 19;4(10):e7505. doi: 10.1371/journal.pone.0007505.
4
Mouse ribosomal RNA genes contain multiple differentially regulated variants.小鼠核糖体RNA基因包含多个差异调控的变体。
PLoS One. 2008 Mar 26;3(3):e1843. doi: 10.1371/journal.pone.0001843.
5
Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium.无β-连环蛋白突变会损害小鼠角膜上皮的稳态和伤口修复。
PLoS One. 2007 Oct 31;2(10):e1087. doi: 10.1371/journal.pone.0001087.
6
Basonuclin regulates a subset of ribosomal RNA genes in HaCaT cells.Basonuclin 调控 HaCaT 细胞中一组核糖体 RNA 基因。
PLoS One. 2007 Sep 19;2(9):e902. doi: 10.1371/journal.pone.0000902.
7
ZAS: C2H2 zinc finger proteins involved in growth and development.ZAS：参与生长发育的C2H2型锌指蛋白。
Gene Expr. 2002;10(4):137-52. doi: 10.3727/000000002783992479.