Berndt U, Hinnen U, Iliev D, Elsner P
Department of Dermatology, University Hospital, Zurich, Switzerland.
Dermatology. 1999;198(4):351-4. doi: 10.1159/000018147.
Since identification of subjects with high eczema risk by screening tests is desirable, different skin bioengineering methods were studied for their validity as predictive measures for the development of hand eczema.
205 metalworker trainees were followed up over 2.5 years from the beginning of their apprenticeship to observe the occurrence of hand eczema. Within the first weeks of their training they underwent a number of noninvasive biophysical tests. Transepidermal water loss, skin moisture and skin roughness were measured, and irritation tests with dimethyl sulfoxide (DMSO), sodium hydroxide (NaOH) and sodium lauryl sulfate were conducted. Sensitivity, specificity and predictive values of the performed tests and test combinations were calculated.
None of the observed single biophysical methods can be considered a valid screening test.
A combination of short irritation tests (DMSO and NaOH tests) and the measurement of skin moisture, however, allows to identify individuals at high risk for hand dermatitis with a high sensitivity, though low specificity.
由于通过筛查试验识别高湿疹风险个体是可取的，因此研究了不同的皮肤生物工程方法作为手部湿疹发生预测指标的有效性。
对205名金属加工行业学徒从学徒期开始进行了2.5年的随访，以观察手部湿疹的发生情况。在培训的最初几周内，他们接受了多项非侵入性生物物理测试。测量了经表皮水分流失、皮肤水分和皮肤粗糙度，并进行了二甲基亚砜（DMSO）、氢氧化钠（NaOH）和十二烷基硫酸钠的刺激性试验。计算了所进行测试及测试组合的敏感性、特异性和预测值。
所观察到的单一生物物理方法均不能被视为有效的筛查试验。
然而，短期刺激性试验（DMSO和NaOH试验）与皮肤水分测量相结合，虽特异性较低，但能以较高的敏感性识别手部皮炎的高危个体。
