Schliemann-Willers Sibylle, Fuchs Silke, Kleesz Peter, Grieshaber Romano, Elsner Peter
Department of Dermatology, Friedrich-Schiller-University, Erfurter Strasse 35, DE-07740 Jena, Germany.
Acta Derm Venereol. 2005;85(3):206-10. doi: 10.1080/00015550410025444.
Combined exposure to different irritants in the workplace may lead to irritant contact dermatitis, which is the main type of occupational dermatitis among bakers and confectioners. Following previous work on "tandem irritation", a panel of healthy volunteers was exposed twice daily for 4 days to the organic fruit acids: citric, malic, and lactic acid, either alone or in tandem application with 0.5% sodium lauryl sulphate (SLS) in a repetitive irritation test. Irritant cutaneous reactions were quantified by visual scoring and non-invasive measurement of transepidermal water loss and skin colour reflectance. Twice daily application of either citric or malic acid alone did not induce a significant irritant reaction. Combined exposure to one of the fruit acids and SLS caused marked barrier disturbance, but the latter irritant effect was smaller than that obtained by combined exposure to SLS and water. Thus, combined exposure to the above-mentioned fruit acids and SLS did not enhance cumulative skin irritation.
在工作场所同时接触不同的刺激物可能会导致刺激性接触性皮炎，这是面包师和糖果师中职业性皮炎的主要类型。继之前关于“串联刺激”的研究之后，一组健康志愿者在重复刺激试验中，每天两次、连续4天接触有机果酸（柠檬酸、苹果酸和乳酸），单独接触或与0.5%月桂醇硫酸酯钠（SLS）串联接触。通过视觉评分以及经皮水分流失和皮肤颜色反射率的非侵入性测量对刺激性皮肤反应进行量化。每天两次单独使用柠檬酸或苹果酸均未引起明显的刺激反应。果酸之一与SLS联合接触会导致明显的屏障破坏，但后一种刺激作用小于SLS与水联合接触所产生的刺激作用。因此，上述果酸与SLS联合接触不会增强累积性皮肤刺激。
