端粒酶在颅内肿瘤中的表达：恶性胶质瘤和脑膜瘤的预后潜力
Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas.
作者信息
Falchetti M L, Pallini R, Larocca L M, Verna R, D'Ambrosio E
机构信息
Istituto di Medicina Sperimentale, CNR, Rome, Italy.
出版信息
J Clin Pathol. 1999 Mar;52(3):234-6. doi: 10.1136/jcp.52.3.234.
AIM
To evaluate the diagnostic value of telomerase expression in intracranial tumours.
METHODS
98 surgical specimens from different neoplasms were analysed by the telomeric repeat amplification protocol (TRAP) and the presence of telomerase compared with the histological diagnosis and the proliferation index.
RESULTS
A high degree of positivity for telomerase activity was found in glioblastomas and atypical/anaplastic meningiomas. Telomerase activity was poorly detected in anaplastic astrocytomas.
CONCLUSIONS
The TRAP assay seems to be a valuable index for identifying meningeal tumours with aggressive behaviour.
目的
评估端粒酶表达在颅内肿瘤中的诊断价值。
方法
采用端粒重复序列扩增法（TRAP）分析98例来自不同肿瘤的手术标本，并将端粒酶的存在情况与组织学诊断及增殖指数进行比较。
结果
在胶质母细胞瘤和非典型/间变性脑膜瘤中发现端粒酶活性高度阳性。在间变性星形细胞瘤中，端粒酶活性检测结果不佳。
结论
TRAP检测似乎是识别具有侵袭性行为的脑膜肿瘤的一个有价值的指标。
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