脑肿瘤：研究与样本库的特殊特征
Brain tumors: Special characters for research and banking.
作者信息
Kheirollahi Majid, Dashti Sepideh, Khalaj Zahra, Nazemroaia Fatemeh, Mahzouni Parvin
机构信息
Department of Genetics and Molecular Biology and Pediatrics Inherited Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Adv Biomed Res. 2015 Jan 6;4:4. doi: 10.4103/2277-9175.148261. eCollection 2015.
Abstract
A brain tumor is an intracranial neoplasm within the brain or in the central spinal canal. Primary malignant brain tumors affect about 200,000 people worldwide every year. Brain cells have special characters. Due to the specific properties of brain tumors, including epidemiology, growth, and division, investigation of brain tumors and the interpretation of results is not simple. Research to identify the genetic alterations of human tumors improves our knowledge of tumor biology, genetic interactions, progression, and preclinical therapeutic assessment. Obtaining data for prevention, diagnosis, and therapy requires sufficient samples, and brain tumors have a wide range. As a result, establishing the bank of brain tumors is very important and essential.
摘要
脑肿瘤是指发生于脑内或中央椎管内的颅内肿瘤。每年全球约有20万人受原发性恶性脑肿瘤影响。脑细胞具有特殊性质。由于脑肿瘤的特殊属性，包括流行病学、生长和分裂等方面，对脑肿瘤的研究以及结果解读并非易事。识别人类肿瘤基因改变的研究有助于我们增进对肿瘤生物学、基因相互作用、进展及临床前治疗评估的了解。获取预防、诊断和治疗所需的数据需要足够的样本，而脑肿瘤种类繁多。因此，建立脑肿瘤库非常重要且必要。
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