Cohen M R, Reda D J, Clegg D O
Medical College of Wisconsin, Milwaukee, USA.
J Rheumatol. 1999 Aug;26(8):1752-6.
To determine differences in disease onset, extent, and manifestations of psoriasis among patients with active, inflammatory psoriatic arthritis (PsA), and to examine relationships that may exist between psoriasis and PsA.
Baseline demographic, clinical, and laboratory data were analyzed from 221 patients enrolled in a multicenter cooperative study, and relationships between measures of psoriasis and PsA were determined.
Mean percentage of body surface area (BSA) affected by psoriasis was modest (12+/-17), and mean severity of erythema, induration, and scaling was moderate (4.9+/-2.1 on a 0-9 scale). Spanish Americans tended to have a higher mean percentage of BSA (18.5%) than Caucasians (11%; p = 0.067), as well as higher target lesion severity (5.55 vs. 4.84; p = 0.077). Patients with psoriatic nail disease (180/221, 81%) had significantly greater number of involved distal interphalangeal (DIP) joints (p = 0.004). There were no other significant associations of skin pattern or regional involvement with PsA.
Patients with active PsA have generally mild skin disease, and baseline relationships between psoriasis and PsA tend to be weak except for nail involvement and DIP joint activity.
确定活动性炎症性银屑病关节炎（PsA）患者中银屑病的发病、范围及表现的差异，并研究银屑病与PsA之间可能存在的关系。
对纳入一项多中心合作研究的221例患者的基线人口统计学、临床和实验室数据进行分析，并确定银屑病与PsA各项指标之间的关系。
银屑病累及的体表面积（BSA）平均百分比适中（12±17），红斑、硬结和鳞屑的平均严重程度为中度（0-9分制下为4.9±2.1）。西班牙裔美国人的BSA平均百分比（18.5%）往往高于白种人（11%；p = 0.067），靶皮损严重程度也更高（5.55对4.84；p = 0.077）。银屑病甲病患者（180/221，81%）累及的远端指间（DIP）关节数量显著更多（p = 0.004）。皮肤类型或受累部位与PsA无其他显著关联。
活动性PsA患者的皮肤疾病通常较轻，除了甲受累和DIP关节活动外，银屑病与PsA之间的基线关系往往较弱。
