The Rockefeller University, New York, New York, United States of America.
PLoS One. 2011;6(6):e20279. doi: 10.1371/journal.pone.0020279. Epub 2011 Jun 1.
This study correlated assessment tools for evaluating the severity of skin, nail, and joint symptoms in patients with psoriasis (Pso) and psoriatic arthritis (PsA). Adults with plaque Pso (with or without PsA) were enrolled from four U.S. institutions. Patients were evaluated using a novel 10-area Linear Psoriasis Area and Severity Index (XL-PASI), Psoriatic Arthritis Assessment (PsAA), Psoriatic Arthritis Screening and Evaluation Questionnaire (PASE), Nail Assessment (NA) and Joint Assessment (JA) tools, Psoriasis Weighted Extent and Severity Index (PWESI), and Lattice Physician Global Assessment (LS-PGA). Correlations between assessment tools and individual items in the assessment tools were performed. Data from 180 patients (55 with PsA) were analyzed. Highest correlations between tools (r = 0.77-0.88) were between the XL-PASI, PWESI and LS-PGA. Individual items in the XL-PASI correlated with items in the PWESI for extent skin symptoms, but not for all body areas. Overall, correlations were seen between hands and feet, between face and scalp, and between buttocks, chest, and back. Only low correlation was seen between items assessing joint symptoms with items assessing skin symptoms. These data support the notion that the complex phenotype of psoriatic disease requires instruments that assess the severity of skin, nails, and joints separately.
本研究对评估银屑病（Pso）和银屑病关节炎（PsA）患者皮肤、指甲和关节症状严重程度的评估工具进行了相关性分析。从美国的四家机构招募了患有斑块型 Pso（伴或不伴 PsA）的成年患者。患者使用新型的 10 区域线性银屑病面积和严重程度指数（XL-PASI）、银屑病关节炎评估（PsAA）、银屑病关节炎筛查和评估问卷（PASE）、指甲评估（NA）和关节评估（JA）工具、银屑病加权严重程度指数（PWESI）和网格医生整体评估（LS-PGA）进行评估。对评估工具之间的相关性和评估工具中的单项进行了分析。对 180 名患者（55 名患有 PsA）的数据进行了分析。工具之间的相关性最高（r = 0.77-0.88）是在 XL-PASI、PWESI 和 LS-PGA 之间。XL-PASI 的单项与 PWESI 的皮肤症状严重程度单项相关，但并非所有身体区域都相关。总体而言，手和脚、面部和头皮、臀部、胸部和背部之间都存在相关性。只有评估关节症状的项目与评估皮肤症状的项目之间存在低度相关性。这些数据支持这样一种观点，即银屑病的复杂表型需要评估皮肤、指甲和关节严重程度的单独仪器。
