Rohrer C R, Hill R C, Fischer A, Fox L E, Schaer M, Ginn P E, Casanova J M, Burrows C F
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126, USA.
Am J Vet Res. 1999 Aug;60(8):977-81.
To determine whether healthy dogs given high doses of methylprednisolone sodium succinate (MPSS) develop gastrointestinal tract ulcers and hemorrhage.
19 healthy male hound-type dogs.
Dogs were assigned randomly to intravenously receive high doses of MPSS (30 mg/kg of body weight, initially, then 15 mg/kg 2 and 6 hours later, and, subsequently, every 6 hours for a total of 48 hours; n = 10) or an equal volume of saline (0.9% NaCl) solution (9). Gastroduodenoscopy was performed before and after treatment. Endoscopic evidence of gross hemorrhage in the cardia, fundus, antrum, and duodenum of each dog was graded from none (0) to severe (3), and a total stomach score was calculated as the sum of the regional gastric scores. Number of ulcers were recorded. The pH of gastric fluid and evidence of occult gastric and fecal blood were measured. Food retention was recorded.
Gastric hemorrhage was evident in all dogs after MPSS administration and was severe in 9 of 10 dogs but not visible in any dog after saline treatment. Occult gastric blood was detected more commonly (9/10 vs 2/9), median gastric acidity was greater (pH 1 vs pH 3), and food was retained more commonly (7/10 vs 1/9) in the stomach of MPSS-treated dogs.
High doses of MPSS cause gastric hemorrhage in dogs. All dogs treated with high doses of MPSS should be treated with mucosal protectants or antacids to prevent gastric hemorrhage.
确定给予高剂量琥珀酸甲泼尼龙（MPSS）的健康犬是否会发生胃肠道溃疡和出血。
19只健康雄性猎犬型犬。
将犬随机分为两组，一组静脉注射高剂量MPSS（初始剂量为30mg/kg体重，然后在2小时和6小时后分别给予15mg/kg，随后每6小时给药一次，共48小时；n = 10），另一组静脉注射等体积的生理盐水（0.9% NaCl溶液）（9只）。在治疗前后进行胃十二指肠镜检查。对每只犬的贲门、胃底、胃窦和十二指肠的大出血内镜证据进行分级，从无（0级）到严重（3级），并计算总胃评分，即各区域胃评分之和。记录溃疡数量。测量胃液pH值以及胃和粪便潜血证据。记录食物潴留情况。
给予MPSS后，所有犬均出现胃出血，10只犬中有9只出血严重，而生理盐水治疗后所有犬均未见明显出血。MPSS治疗的犬胃潜血更常见（9/10比2/9），胃液酸度中位数更高（pH值1比pH值3），胃内食物潴留更常见（7/10比1/9）。
高剂量MPSS可导致犬胃出血。所有接受高剂量MPSS治疗的犬都应使用黏膜保护剂或抗酸剂进行治疗，以预防胃出血。
