Missov E D, De Marco T
Division of Cardiology, University of California, San Francisco 94143-0124, USA.
Clin Chim Acta. 1999 Jun 30;284(2):175-85. doi: 10.1016/s0009-8981(99)00079-0.
This review describes the pathophysiological and histopathological rationale for using the cardiac isoforms of troponin T and troponin I in congestive heart failure (CHF). It also focuses on the potential clinical usefulness of new generation highly sensitive and specific cardiac troponin assays with respect to histological monitoring, risk stratification and therapeutic follow-up of patients with CHF. The availability of more powerful analytical tools for these highly specific markers of myocardial injury offers a unique opportunity to expand the field of their application and to explore new disease processes. Because cardiac troponin T and cardiac troponin I provide useful clinical information unavailable through other diagnostic techniques, they appear as promising biochemical markers in patients with CHF.
本综述阐述了在充血性心力衰竭（CHF）中使用肌钙蛋白T和肌钙蛋白I的心脏同工型的病理生理学和组织病理学依据。它还聚焦于新一代高灵敏度和特异性心脏肌钙蛋白检测在CHF患者的组织学监测、风险分层及治疗随访方面的潜在临床应用价值。针对这些心肌损伤高度特异性标志物的更强大分析工具的出现，为拓展其应用领域及探索新的疾病进程提供了独特机遇。由于心脏肌钙蛋白T和心脏肌钙蛋白I能提供其他诊断技术无法获得的有用临床信息，它们在CHF患者中似乎是很有前景的生化标志物。
