一种在人体结肠释放药物的口服制剂。
An oral preparation to release drugs in the human colon.
作者信息
Dew M J, Hughes P J, Lee M G, Evans B K, Rhodes J
出版信息
Br J Clin Pharmacol. 1982 Sep;14(3):405-8. doi: 10.1111/j.1365-2125.1982.tb01999.x.
Abstract
1 A colonic delivery system is described to deliver orally ingested drugs to the colon and release them at that site by coating with an acrylic based resin (Eudragit S). The technique is validated using X-ray evidence and serum levels of a convenient marker, sulphapyridine. 2 This colonic delivery system is particularly suitable for drugs such as 5-amino salicylic acid or steroids in the management of patients with colitis.
摘要
- 描述了一种结肠给药系统，该系统通过用丙烯酸基树脂（Eudragit S）包衣，将口服摄入的药物输送到结肠并在该部位释放。该技术通过X射线证据和一种方便的标记物磺胺吡啶的血清水平进行了验证。2. 这种结肠给药系统特别适用于治疗结肠炎患者时使用的5-氨基水杨酸或类固醇等药物。
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