Kasuga T, Sawada M, Nogami M, Abe Y
Department of Materials Science and Engineering, Nagoya Institute of Technology, Japan.
Biomaterials. 1999 Aug;20(15):1415-20. doi: 10.1016/s0142-9612(99)00047-2.
Novel glass-ceramics were synthesized via sintering and crystallization by heating powder compacts of SiO2-free calcium phosphate invert glasses of 60CaO x 30P2O5 x 7Na2O x 3TiO2 or 60CaO x 30P2O5 x 7Na2O x 3MgO at 800-850 degrees C in air. The glass-ceramics were relatively dense materials consisting of crystalline phases such as beta-Ca3(PO4)2 and beta-Ca2P2O7 with glassy phases. The compacts were densified by the viscous flow of the glassy phases while heating. By soaking in simulated body fluid at 37 degrees C, a calcium phosphate phase was formed newly on the surface of the glass-ceramic derived from 60CaO x 30P2O5 x 7Na2O x 3TiO2 glass, while the phase was not formed on that derived from 60CaO x 30P2O5 x 7Na2O x 3MgO glass: the former was implied to show bioactivity. Composition of the glassy phase as the matrix varies with the additives such as TiO2 and MgO, and the chemical properties of the phase influence the bioactivity of the glass-ceramics. The glass-ceramic derived from 60CaO x 30P2O5 x 7Na2O x 3TiO2 glass has relatively high fracture toughness of K(IC) approximately 2 MPa m(0.5) and bending strength of 100-120 MPa.
通过在空气中于800 - 850摄氏度加热60CaO x 30P2O5 x 7Na2O x 3TiO2或60CaO x 30P2O5 x 7Na2O x 3MgO的无SiO2磷酸钙反玻璃粉末压块，经烧结和结晶合成了新型玻璃陶瓷。这些玻璃陶瓷是相对致密的材料，由β - Ca3(PO4)2和β - Ca2P2O7等晶相以及玻璃相组成。加热时，压块通过玻璃相的粘性流动而致密化。将其浸泡在37摄氏度的模拟体液中时，源自60CaO x 30P2O5 x 7Na2O x 3TiO2玻璃的玻璃陶瓷表面新形成了磷酸钙相，而源自60CaO x 30P2O5 x 7Na2O x 3MgO玻璃的玻璃陶瓷表面未形成该相：这表明前者具有生物活性。作为基体的玻璃相组成随TiO2和MgO等添加剂而变化，该相的化学性质影响玻璃陶瓷的生物活性。源自60CaO x 30P2O5 x 7Na2O x 3TiO2玻璃的玻璃陶瓷具有相对较高的断裂韧性，K(IC)约为2 MPa m(0.5)，弯曲强度为100 - 120 MPa。
