Popot M A, Lacabaratz E, Garcia P, Laroute V, Bonnaire Y, Toutain P L, Cowan D A
L.A.B., Chatenay Malabry, France.
Equine Vet J. 1999 Jul;31(4):278-84. doi: 10.1111/j.2042-3306.1999.tb03817.x.
The cortisol threshold concentration of 1.0 microg/ml in horse urine adopted by the International Federation of the racing Authorities in 1994 is specific. However, an increase in the sensitivity for the detection of cortisol administration would be helpful. Previous studies have shown that 20beta-dihydrocortisol concentration in urine would be a good indicator of cortisol administration. The purpose of the present work was to estimate the population parameters and the critical values of 20beta-dihydrocortisol and 20beta-dihydrocortisone concentration in urine compared with that of cortisol. Using the same probability (1.1 x 10(-4)) which was used for the establishment of the official cortisol threshold, the critical values of 5000 ng/ml for 20beta-dihydrocortisol and 350 ng/ml for 20beta-dihydrocortisone were obtained. Considering these 2 critical values for 20beta-dihydrocortisol and 20beta-dihydrocortisone, the time during which a horse could be declared positive is significantly increased.
国际赛马管理机构联合会于1994年采用的马尿中皮质醇阈值浓度为1.0微克/毫升，该阈值具有特异性。然而，提高检测皮质醇给药的灵敏度会有所帮助。先前的研究表明，尿中20β - 双氢皮质醇浓度是皮质醇给药的良好指标。本研究的目的是评估与皮质醇相比，尿中20β - 双氢皮质醇和20β - 双氢可的松浓度的总体参数和临界值。使用用于确定官方皮质醇阈值的相同概率（1.1×10⁻⁴），得出20β - 双氢皮质醇的临界值为5000纳克/毫升，20β - 双氢可的松的临界值为350纳克/毫升。考虑到20β - 双氢皮质醇和20β - 双氢可的松的这两个临界值，一匹马可被判定为阳性的时间显著增加。
