Maciag P C, Villa L L
Instituto Ludwig de Pesquisa sobre o Câncer, São Paulo, Brasil.
Braz J Med Biol Res. 1999 Jul;32(7):915-22. doi: 10.1590/s0100-879x1999000700017.
Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation.
宫颈鳞状细胞癌（SCCC）是发展中国家主要的死亡原因之一。高危型人乳头瘤病毒（HPV）感染是宫颈发生恶性病变的主要危险因素。尽管有相互矛盾的数据报道，但MHC和p53基因的多态性似乎会影响HPV感染的结果以及向SCCC的进展。MHC是高度多态性的基因，编码参与抗原呈递的分子，在免疫调节中起关键作用，而p53是一种调节细胞增殖的肿瘤抑制基因。高危型HPV的E6蛋白与p53结合，并通过泛素途径介导其降解。这些多态性在HPV感染和SCCC遗传易感性中的作用仍在研究中。
