de Koe W J
Ministry of Public Health, Wageningen, The Netherlands.
Arh Hig Rada Toksikol. 1999 Mar;50(1):37-46.
Mycotoxins are fungal metabolites that are present in a large part of the world food supply and bear potential threat to food safety. The European Union has been working for several years now on the harmonization of some mycotoxin standards for foods based on toxicological evaluation by its Scientific Committee on Food (SCF). These standards will follow the ALARA (as low as reasonably achievable) principle and will be applied to aflatoxins in the first place followed by ochratoxin A, patulin, and several toxins from Fusarium spp. Detailed regulations (limits, methods of sampling, and analysis) for aflatoxins B, G, and M on the commodities at stake have been worked out. At the moment, a variety of interrelated approaches as to the intake and toxicity of ochratoxin A are being discussed to assess the hazards and to determine the associated risk of this toxin. The other toxins like patulin and the ones derived from Fusarium spp. such as zearalenon and fumonisins will be discussed in the years to come.
霉菌毒素是真菌代谢产物,存在于世界上大部分的食物供应中,对食品安全构成潜在威胁。欧盟多年来一直在根据其食品科学委员会(SCF)的毒理学评估,致力于协调食品中某些霉菌毒素标准。这些标准将遵循“尽可能低合理可行”(ALARA)原则,首先适用于黄曲霉毒素,其次是赭曲霉毒素A、展青霉素以及镰刀菌属产生的几种毒素。针对相关商品中黄曲霉毒素B、G和M的详细法规(限量、采样和分析方法)已经制定出来。目前,正在讨论关于赭曲霉毒素A摄入和毒性的各种相互关联的方法,以评估危害并确定该毒素的相关风险。其他毒素,如展青霉素以及镰刀菌属产生的毒素,如玉米赤霉烯酮和伏马菌素,将在未来几年进行讨论。