Bridler R, Howald A
Psychiatrische Universitätsklinik Zürich.
Psychiatr Prax. 1999 Jul;26(4):202-4.
Malignant catatonia is a rare, life-threatening syndrome that occurs in connection with somatic as well as psychiatric disorders, in particular with functional psychosis. Key symptoms are catatonic features combined with elevated muscle tone, hyperthermia, vegetative instability, and pathological laboratory values. Benzodiazepines, dantrolene, and ECT have been reported to be an effective treatment of malignant catatonia, whereas classic neuroleptics and anticholinergic drugs are contraindicated. If antipsychotic treatment is required, clozapine is generally used. In this article we describe a case of malignant catatonia in a 52 year old female patient and discuss the clinical picture, the treatment, and the time course of the syndrome.
恶性紧张症是一种罕见的、危及生命的综合征，与躯体疾病以及精神疾病相关，尤其是与功能性精神病有关。关键症状是紧张症特征合并肌张力升高、体温过高、自主神经功能不稳定以及异常的实验室检查值。据报道，苯二氮䓬类药物、丹曲林和电休克治疗（ECT）是治疗恶性紧张症的有效方法，而经典抗精神病药物和抗胆碱能药物则属禁忌。如果需要进行抗精神病治疗，一般使用氯氮平。在本文中，我们描述了一名52岁女性患者的恶性紧张症病例，并讨论了该综合征的临床表现、治疗方法及病程。
