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[抗精神病药恶性综合征与急性危及生命的紧张症——两种截然不同的疾病实体?]

[Neuroleptic malignant syndrome and acute life-threatening catatonia--two contrasting disease entities?].

作者信息

Heils A, Lesch K P

机构信息

Psychiatrische Klinik und Poliklinik, Universität Würzburg.

出版信息

Fortschr Neurol Psychiatr. 1997 Jan;65(1):8-15.

PMID:9132369
Abstract

They are rare but dangerous complications in the course of acute psychotic diseases. A differential diagnose between these units, based on clinical symptoms, is impossible. Moreover the literature of the last years reveals, that the Malignant Neuroleptic Syndrome and Lethal Catatonia are identical complications in functional psychoses. This is also supported by the evidence of therapeutical consequences. In each case neuroleptics appear generally inadequate, and the interruption of neuroleptic medication is necessary, otherwise they would aggravate the disorder. An efficient supplementary treatment is the ECT.

摘要

它们是急性精神病病程中罕见但危险的并发症。基于临床症状对这些病症进行鉴别诊断是不可能的。此外,近年来的文献表明,恶性抗精神病药物综合征和致死性紧张症在功能性精神病中是相同的并发症。这也得到了治疗结果证据的支持。在每种情况下,抗精神病药物通常似乎都不合适,必须中断抗精神病药物治疗,否则会加重病情。有效的辅助治疗是电休克治疗(ECT)。

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